Cyclocarysaponins A–J,dammarane-type triterpenoid glycosides from the leaves of Cyclocarya paliurus  

作　　者：XI Huiting YUAN Mingming XIE Jianhua WANG Yuanxing 

机构地区：[1]State Key Laboratory of Food Science and Resources,Nanchang University,Nanchang 330047,China [2]Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality,Nanchang 330029,China

出　　处：《Chinese Journal of Natural Medicines》2024年第10期955-964,共10页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.31960090 and 32160562);the State Key Laboratory of Food Science and Resources,Nanchang University(No.SKLF-ZZB-202129)。

摘　　要：Ten previously undescribed dammarane-type triterpenoid glycosides,cyclocarysaponins A–J(1–10),were isolated from the leaves of Cyclocarya paliurus(Batal.)Iljinskaja.The structures of these compounds were characterized through detailed spectroscopic analysis,including 1D and 2D nuclear magnetic resonance(NMR)and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS).The cytotoxic activities of all isolates were assessed against five human cancer cell lines(Bel-7402,Caski,BGC-823,A2780,and HCT-116).Of the tested compounds,compounds 1,7,and 9 exhibited selective cytotoxicity against one or more human cancer cell lines.

关 键 词：Cyclocarya paliurus JUGLANDACEAE Triterpenoid glycosides Cyclocarysaponin Cytotoxic activities 

分 类 号：R284.1[医药卫生—中药学]