肠道微生物群对骨代谢调节作用的研究进展  

The regulation of bone metabolism by gut microbiota:research progress

作　　者：许振东 王贺双[2] 李华军 邵华[4] 安晓华[4] 都庄 王鑫[1] 周朋 XU Zhendong;WANG Heshuang;LI Huajun;SHAO Hua;AN Xiaohua;DU Zhuang;WANG Xin;ZHOU Peng(Department of Sports Medicine,Dalian Municipal Central Hospital,Dalian,Liaoning 116033,China;不详)

机构地区：[1]大连市中心医院运动医学科,辽宁116033 [2]大连市中心医院中心实验室 [3]大连医科大学基础医学院微生态学教研室 [4]大连市中心医院输血科 [5]大连市中心医院第一手术室

出　　处：《中国微生态学杂志》2024年第9期1112-1116,共5页Chinese Journal of Microecology

摘　　要：骨骼通过不断地更新来保障其完整性和生理活动,成骨细胞和破骨细胞是骨更新过程中非常关键的细胞,二者达到动态平衡才能实现骨稳态;反之,则影响骨代谢,甚至进展为骨质疏松症。骨质疏松症发病率高,病情隐匿,往往以骨质疏松性骨折的形式而被确诊,严重影响预后,骨质疏松性骨折是老年人残疾和死亡的主要原因之一。已知肠道微生物群数量庞大,与人类的各种疾病都显著相关,“肠道微生物群-骨轴”也受到越来越多的关注。肠道微生物群已被发现可介导代谢、免疫系统和神经内分泌系统,从而影响成骨细胞和(或)破骨细胞的增殖与分化,进而破坏骨稳态。本文就肠道微生物群对骨代谢的影响和作用机制的研究进展作一综述。Bone guarantees its integrity and physiological activity through continuous renewal.During this process osteoblasts and osteoclasts are two critical cells.They can ensure the bone homeostasis only when they reach a dynamic balance.Without the dynamic balance,bone metabolism will be interfered and even progress to osteoporosis.The disease is not only highly prevalent but also insidious,frequently diagnosed in the form of osteoporotic fracture,which is one of the major causes of disability and death in the elderlies.The gut microbiota is known to be innumerable,and has a clear correlation with various diseases of human.The"gut microbiota-bone axis"has also received increasing attention.The gut microbiota has been found to mediate metabolites,immune system and neuroendocrine system to affect the proliferation and differentiation of osteoblasts and/or osteoclasts,thereby disrupting bone homeostasis.This review summarizes the progress in research on gut microbiota acting on bone metabolism and its mechanisms.

关 键 词：肠道微生物群 骨代谢 T淋巴细胞 短链脂肪酸 5-羟色胺 

分 类 号：R372[医药卫生—病原生物学]