血清及组织miR-205预测卵巢型子宫内膜异位症术后复发价值  

Predictive Value of Serum and Tissue miR-205 for Postoperative Recurrence of Ovarian-type Endometriosis

作　　者：崔培林 宋玉霞 王雪娟 CUI Peilin;SONG Yuxia;WANG Xuejuan(Dept.of Gynecology,Shijiazhuang People’s Hospital,Shijiazhuang Hebei 050000,China)

机构地区：[1]石家庄市人民医院妇科,河北石家庄050000

出　　处：《昆明医科大学学报》2024年第10期105-110,共6页Journal of Kunming Medical University

基　　金：石家庄市科学技术研究与发展计划项目(201460613)。

摘　　要：目的探讨血清及组织miR-205预测卵巢型子宫内膜异位症(EMT)术后复发价值。方法选取2019年6月至2021年6月石家庄市人民医院收治的100例卵巢型EMT患者,均接受腹腔镜手术,根据术后24个月复发情况分为复发组(n=24)和未复发组(n=76),比较2组一般资料、血清及子宫内膜组织癌抗原125(CA125)、miR-205,Spearman分析CA125与miR-205相关性,绘制受试者工作特征曲线(ROC)及曲线下面积(AUC)分析miR-205、CA125预测卵巢型EMT术后复发效能,采用DeLong检验miR-205、CA125预测卵巢型EMT术后复发AUC差异。结果2组一般资料比较差异无统计学意义(P>0.05);复发组r-AFS分期血清及子宫异位内膜组织CA125含量高于未复发组,血清及子宫异位内膜组织miR-205表达低于未复发组(P<0.05);卵巢型EMT术后复发患者血清及子宫内膜组织miR-205与CA125呈负相关(r=-0.728、-0.713,均P<0.001);ROC曲线显示,血清、子宫异位内膜组织miR-205预测卵巢型EMT术后复发的AUC为0.741、0.809。DeLong检验显示,血清、子宫异位内膜组织miR-205与CA125预测卵巢型EMT术后复发的AUC比较差异无统计学意义(Z值为0.020,P为0.951)。结论卵巢型EMT术后复发患者血清及子宫异位内膜组织miR-205呈低表达,与CA125呈负相关,测定血清及子宫异位内膜组织miR-205有助于提高预测效能,指导临床治疗。Objective To explore the predictive value of serum and tissue miR-205 for postoperative recurrence of ovarian-type endometriosis(EMT).Methods A total of 100 patients with ovarian-type EMT who were treated at Shijiazhuang People's Hospital from June 2019 to June 2021 were selected.All patients underwent laparoscopic surgery and were divided into a recurrence group(n=24)and a non-recurrence group(n=76)based on their recurrence status 24 months post-surgery.The general information,serum,and endometrial tissue cancer antigen 125(CA125),and miR-205 levels were compared between the two groups.Spearman's correlation was used to analyze the correlation between CA125 and miR-205.Receiver operating characteristic(ROC)curves and area under the curve(AUC)were plotted to analyze the predictive efficacy of miR-205 and CA125 for postoperative recurrence of ovarian EMT.The DeLong test was used to compare the differences in AUC between miR-205 and CA125 for predicting postoperative recurrence of ovarian EMT.Results There was no significant difference in the general data between the two groups(P>0.05).The CA125 levels in serum and ectopic endometrial tissue of the recurrent group were higher than those in the non-recurrent group,while the expression of miR-205 in serum and ectopic endometrial tissue was lower than that in the non-recurrent group(P<0.05).There was a negative correlation between miR-205 and CA125 in serum and endometrial tissue of patients with ovarian EMT recurrence after surgery(r=-0.728,-0.713,both P<0.001).The ROC curve showed that the AUC of miR-205 in serum and ectopic endometrial tissue for predicting ovarian EMT recurrence after surgery was 0.741 and 0.809,respectively.The DeLong test showed no significant difference in the AUC of miR-205 in serum and ectopic endometrial tissue compared with CA125 for predicting ovarian EMT recurrence after surgery(Z=0.020,P=0.951).Conclusion The low expression of miR-205 in serum and ectopic endometrial tissue of patients with ovarian EMT recurrence after surgery is negativ

关 键 词：子宫内膜异位症 腹腔镜手术 复发 血清 子宫内膜组织 miR-205 

分 类 号：R711[医药卫生—妇产科学]