三七皂苷R1药理作用机制与神经保护作用研究进展  

Progress on mechanism of action and neuroprotective effects of notoginsenoside R1

作　　者：王汉隆 孙洋 刘莎莎 龙俊鹏 颜倩 林玉婷 梁金萍 楚世峰[4] 杨岩涛[1,2] 艾启迪 陈乃宏 WANG Han-long;SUN Yang;LIU Sha-sha;LONG Jun-peng;YAN Qian;LIN Yu-ting;LIANG Jin-ping;CHU Shi-feng;YANG Yan-tao;AI Qi-di;CHEN Nai-hong(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces,Changsha 410208,China;Changsha Hospital for Maternal and Child Health Care Affiliated to Hunan Normal Uiversity,Changsha 410007,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙410208 [3]湖南师范大学附属长沙市妇幼保健院,湖南长沙410007 [4]中国医学科学院&北京协和医学院药物研究所,北京100050

出　　处：《中国药理学通报》2024年第11期2020-2025,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No U2202214);湖南省自然科学基金项目(No 2022JJ40456,2023JJ60471);长沙市妇幼保健院2023年度院级院级科研重点项目(No 202329-2);湖南中医药大学中药学一流学科建设项目。

摘　　要：三七是五加科人参属多年生直立草本植物三七[Panax notoginseng(Burk.)F.H.Chen]干燥根及根茎,作为我国传统中药,具有较好的补益功效,《中药大辞典》有言,三七功用补血,去瘀损,止血衄,能通能补,功效最良,是方药中之最珍贵者。生吃去瘀生新,消肿定痛,止血不留瘀,行血不伤新;熟服可补益健体。三七皂苷R1是三七总皂苷中特征化合物,近些年来,我国老龄化程度不断加剧,神经系统疾病发生率逐年增高,同时,对三七皂苷R1治疗神经疾病的报道增多,其发挥神经保护作用有确切的疗效。该文旨在对三七皂苷R1治疗神经疾病以及作用机制展开综述,为临床用药与新药开发提供一定的理论依据。s:Panax notoginseng is the dried root and rhizome of Panax notoginseng(Burk.)F.H.Chen,a perennial erect herb of the genus Ginseng of the family Wujiaceae.As a traditional Chinese medicine in our country,Panax notoginseng has a good tonic effect,and the Dictionary of Traditional Chinese Medicines has the words that Panax notoginseng is used to tonify the blood,remove the blood stasis and damage,and stop epistaxis.It can also be used to pass the blood and tonify the blood with the best efficacy,and it is the most precious one of the prescription medicines.Eaten raw,it removes blood stasis and generates new blood,subdues swelling and stabilizes pain,stops bleeding without leaving stasis,and promotes blood circulation without hurting the new blood;taken cooked,it can be used to replenish and strengthen the body.Notoginsenoside R1 is a characteristic compound in the total saponin of Panax ginseng.In recent years,China′s aging has been increasing,and the incidence of neurological disorders has been increasing year by year.Meanwhile,reports on notoginsenoside R1 in the treatment of neurological disorders are increasing,and its neuroprotective effects have been exerted with precise efficacy.The purpose of this paper is to review the treatment of neurological diseases and the mechanism of action of notoginsenoside R1,so as to provide a certain theoretical basis for clinical use and new drug development.

关 键 词：三七 三七皂苷R1 作用机制 研究进展 神经系统 神经保护 

分 类 号：R285[医药卫生—中药学]