热应激诱导炎症反应及细胞自噬的调控机制  

Regulatory Mechanism of Heat Stress⁃Induced Inflammatory Response and Autophagy

作　　者：罗烨 刘慧敏 瞿明仁 许兰娇 LUO Ye;LIU Huimin;QU Mingren;XU Lanjiao(Engineering Research Center of Nutrient Feed Development,Jiangxi Key Laboratory of Animal Nutrition,College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,China)

机构地区：[1]江西农业大学动物科学技术学院,江西省动物营养重点实验室,营养饲料开发工程研究中心,南昌330045

出　　处：《动物营养学报》2024年第10期6191-6200,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金项目(32060760)。

摘　　要：自噬是真核细胞在自噬相关基因的调控下利用溶酶体降解自身细胞质蛋白和受损细胞器的过程,可防止组织细胞损伤。热应激可诱导炎症反应和自噬,炎症反应与自噬间相互调控,一方面,炎症的发生可抑制自噬水平,另一方面自噬通过负反馈调节炎症反应,三者间存在复杂的关系。营养与免疫间关系密切,本文从热应激诱导的炎症通路、自噬通路、热应激诱导的炎症与自噬间关系进行整理分析,旨在深入认识热应激、炎症与自噬间的关系,为通过营养调控手段增强自噬缓解热应激诱导炎症损伤提供一定的参考。Autophagy is a process in which eukaryotic cells use lysosomes to degrade their own cytoplasmic proteins and damaged organelles under the regulation of autophagy-related genes,which can prevent tissue and cell damage.Heat stress can induce inflammatory response and autophagy,and inflammatory response and au-tophagy regulate each other.On the one hand,the occurrence of inflammation can inhibit the level of autoph-agy,and on the other hand,autophagy regulates the inflammatory response through negative feedback.There is a complex relationship among the three relations.There is a close relationship between nutrition and immuni-ty.This article summarizes and analyzes the relationship between heat stress-induced inflammation pathways,autophagy pathways,heat stress-induced inflammation and autophagy,aiming to gain a deeper understanding of the relationship between heat stress,inflammation and autophagy.Relationship,providing certain reference for enhancing autophagy to alleviate heat stress-induced inflammatory damage through nutritional regulation.

关 键 词：热应激 炎症反应 细胞自噬 炎症通路 自噬通路 

分 类 号：S811[农业科学—畜牧学]