白藜芦醇药理作用及新型纳米微粒载药系统研究进展  

Research Progress on Pharmacological Effects of Resveratrol and Novel Nanoparticle Drug Delivery System

作　　者：王振涛 丁燕 WANG Zhentao;DING Yan(School of Pharmacy,Changde Vocational Technical College,Changde 415000,China;The First People's Hospital of Changde,Changde 415000,China)

机构地区：[1]常德职业技术学院药学系,湖南常德415000 [2]常德市第一人民医院药剂科,湖南常德415000

出　　处：《山东化工》2024年第19期101-104,共4页Shandong Chemical Industry

基　　金：湖南省教育厅科学研究项目(23C0479)。

摘　　要：白藜芦醇是一种在植物中广泛存在的多酚类化合物,药理研究揭示其具备抗肿瘤、抗炎、抗糖尿病、抗骨质疏松、神经保护等药理作用,因此在医药健康领域具有广泛的应用前景。然而,其水溶解度低、稳定性较差以及生物利用度不高的问题,长期以来制约了其临床开发。本文对近年来白藜芦醇的药理作用及新型纳米微粒载药系统研究进行了归纳总结,以期为白藜芦醇临床制剂的开发提供参考。Resveratrol is a kind of polyphenols widely found in plants.Pharmacological studies have revealed that it has anti-tumor,anti-inflammatory,anti-diabetic,anti-osteoporosis and neuroprotective effects,and has a wide application prospect in the field of medicine and health.However,its low water solubility,poor stability and low bioavailability have restricted its clinical development for a long time.In this paper,the pharmacological effects of resveratrol and new drug delivery systems in recent years were summarized in order to provide reference for the development of clinical preparations of resveratrol.

关 键 词：白藜芦醇 抗肿瘤 神经保护 药理作用 纳米微粒 

分 类 号：TQ461[化学工程—制药化工] R285[医药卫生—中药学]