一种磁共振造影剂的制备及其双模态性能  

Preparation and bimodal properties of a magnetic resonance contrast agent

作　　者：张瀚文 仝耘千 王妮 屈思羽 王月[1] ZHANG Hanwen;TONG Yunqian;WANG Ni;QU Siyu;WANG Yue(School of Chemical Engineering,University of Science and Technology Liaoning,Anshan 114051,China)

机构地区：[1]辽宁科技大学化学工程学院,辽宁鞍山114051

出　　处：《辽宁科技大学学报》2024年第4期281-286,共6页Journal of University of Science and Technology Liaoning

基　　金：辽宁省教育厅项目(LJKMZ20220636)。

摘　　要：磁共振成像(MRI)是目前各种成像技术中最强大的活体成像技术之一,为了提高成像质量以便更加准确地检测和诊断,往往需要使用MRI造影剂。本文以Gd(Ⅲ)的多胺多羧酸类配合物DO3A-Gd和苯并香豆素-3-羧酸(BCCA)为原料,利用原位合成法制备磁共振造影剂DO3A-Gd-BCCA,该造影剂具有磁共振/荧光双模态识别氟离子的性能。通过氟离子取代荧光团BCCA,增加Gd(Ⅲ)周围配位水分子数目和荧光团的电荷迁移,实现磁共振信号和荧光信号的同步激活。该造影剂具有良好的稳定性,适用于生理条件下的pH,对F-的检测限为77μmol/L。Magnetic resonance imaging(MRI)is currently one of the most powerful in vivo imaging techniques.In order to improve the imaging quality for more accurate detection and diagnosis,MRI contrast agents are often needed.This article reports the preparation of an MRI agent DO3A-Gd-BCCA using the in-situ synthesis method with DO3A-Gd and benzocoumarin-3-carboxylic acid(BCCA).The contrast agent also has the ability to recognize fluoride ions in both magnetic resonance and fluorescence modes.By replacing the fluorescent group BCCA with fluoride ions,the number of coordinated water molecules around Gd(Ⅲ)and the charge transfer of the fluorescent group were increased,achieving simultaneous activation of magnetic resonance signals and fluorescence signals.This contrast agent exhibits good stability and is suitable for pH conditions under physiological,with a detection limit of 77μmol/L for F^(-).

关 键 词：造影剂 双模态 氟离子 

分 类 号：O69[理学—化学]