传染性单核细胞增多症患儿EBV-DNA与异型淋巴细胞的相关性  

Correlation between EBV-DNA and Heterogeneous Lymphocytes in Children with Infectious Mononucleosis

作　　者：周小琴 姜良飞 李道霞 ZHOU Xiaoqin;JIANG Liangfei;LI Daoxia(Renhuai City People's Hospital,Renhuai 564500,China;不详)

机构地区：[1]仁怀市人民医院,贵州仁怀564500

出　　处：《中外医学研究》2024年第29期69-72,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析传染性单核细胞增多症(IM)患儿EBV-DNA与异型淋巴细胞的相关性。方法:选取2022年4月—2023年4月仁怀市人民医院收治的48例IM患儿纳入IM组,选取同期48例EBV阴性的发热患儿纳入对照组。两组均进行EBV-DNA及淋巴细胞检测,比较两组相关指标。比较不同病毒载量IM患儿相关指标。分析IM患儿EBV-DNA载量与异型淋巴细胞占比的相关性。结果:IM组EBV-DNA载量、异型淋巴细胞占比、淋巴细胞占比、淋巴细胞计数均高于对照组,差异有统计学意义(P<0.05)。高病毒量患儿与低病毒量患儿淋巴细胞计数、淋巴细胞占比比较,差异无统计学意义(P>0.05),高病毒量组异型淋巴细胞占比、EBV-DNA载量均高于低病毒量IM患儿,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,IM患儿EBV-DNA载量与异型淋巴细胞占比呈正相关(r=0.790,P<0.05)。结论:IM患儿EBV-DNA与异型淋巴细胞检测结果异常,而且EBV-DNA载量与异型淋巴细胞占比呈正相关。Objective:To analyze the correlation between EBV-DNA and heterogeneous lymphocytes in children with infectious mononucleosis(IM).Method:Forty-eight children with IM admitted to Renhuai City People's Hospital from April 2022 to April 2023 were included in the IM group,and 48 children with negative EBV fever were included in the control group during the same period.EBV-DNA and lymphocyte detection were performed in both groups,relevant indicators of the two groups were compared.The relevant indexes of IM children with different viral load were compared.The correlation between EBV-DNA load and the proportion of heterogeneous lymphocytes in children with IM was analyzed.Result:The positive rate of EBV-DNA load,allotypic lymphocyte proportion,lymphocyte proportion and lymphocyte count in IM group were higher than those in control group,and the differences were statistically significant(P<0.05).There was no statistical significance in lymphocyte count and lymphocyte proportion between the children with high viral dose and the children with low viral dose(P>0.05).The proportion of heterogeneous lymphocytes and EBV-DNA load in the high viral dose group were higher than those in the low viral dose IM children,and the differences were statistically significant(P<0.05).The results of Pearson correlation analysis showed that EBV-DNA load was positively correlated with the proportion of heterogeneous lymphocytes in IM children(r=0.790,P<0.05).Conclusion:EBV-DNA and lymphocyte test results were abnormal in children with IM,and EBV-DNA load was positively correlated with the lymphocyte ratio.

关 键 词：传染性单核细胞增多症 相关性 异型淋巴细胞 

分 类 号：R725.1[医药卫生—儿科]