某院血流感染患者产ESBLs大肠埃希菌检出情况、耐药特征及相关因素分析  

Analysis of Detection Status,Drug Resistance Characteristics and Related Factors of ESBLs Producing Escherichia Coli in Patients with Bloodstream Infection in a Hospital

作　　者：赖玉玲 盘健 LAI Yuling;PAN Jian(The First People's Hospital of Shaoguan City,Shaoguan 512099,China;不详)

机构地区：[1]韶关市第一人民医院,广东韶关512099

出　　处：《中外医学研究》2024年第30期138-141,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析某院血流感染(BSI)患者产超广谱β内酰胺酶(ESBLs)大肠埃希菌检出情况、耐药特征及相关因素。方法:选取2021年1月—2023年12月韶关市第一人民医院收治的667例BSI患者作为研究对象,回顾性分析血培养分离病原菌和药敏试验结果等。结果:667例检测样本中,大肠埃希菌阳性最多,占比40.48%,其中产ESBLs大肠埃希菌占15.59%;菌株科室分布主要为重症医学科,占29.69%,呼吸重症医学科占22.04%,消化内科占14.39%。产ESBLs大肠埃希菌对氨苄西林、头孢曲松、头孢呋辛、头孢他啶的耐药率较高,均在90%以上,对亚胺培南、美罗培南药物较为敏感;非产ESBLs大肠埃希菌对氨苄西林耐药率较高为91.57%,对亚胺培南、美罗培南、阿米卡星等较为敏感;相较于非产ESBLs大肠埃希菌,产ESBLs大肠埃希菌对常用抗菌药的耐药性更高。多因素分析结果显示,产ESBLs大肠埃希菌血流感染的危险因素为年龄、住院时间、近3个月使用三代头孢菌素。结论:某院BSI患者中,产ESBLs大肠埃希菌较为常见,其对常用抗菌药的耐药性高,产ESBLs大肠埃希菌的血流感染的发生与患者的年龄、住院天数、近3个月使用三代头孢菌素有关。Objective:To analyze the detection status,drug resistance characteristics and related factors of ESBLs producing Escherichia coli in patients with bloodstream infections(BSI).Method:667 BSI patients admitted to the First People's Hospital of Shaoguan City from January 2021 to December 2023 were selected as the study objects,and the results of blood culture isolation of pathogens and drug susceptibility test were retrospectively analyzed.Result:Among the 667 samples,Escherichia coli was the most positive,accounting for 40.48%,and ESBLs-producing Escherichia coli accounted for 15.59%.The departments of strain were mainly intensive care,accounting for 29.69%.The department of respiratory intensive care accounted for 22.04%,and gastroenterology accounted for 14.39%.The resistance rate of ESBLs-producing Escheriches to ampicillin,ceftriaxone,cefuroxime and ceftazidime was above 90%,and they were sensitive to imipenem and meropenem.The resistance rate of nonESBLs-producing Escherichia coli to ampicillin was 91.57%,and it was sensitive to imipenem,meropenem and Amika magnitude.Compared with non-ESBLs-producing Escherichia coli,ESBLs-producing Escherichia coli had higher resistance to commonly used antibiotics.Multivariate regression analysis showed that the risk factors of ESBLs-producing Escherichia coli bloodstream infection were age,length of hospital stay,and use of third-generation cephalosporins in the past 3 months.Conclusion:ESBLsproducing Escherichia coli is more common in BSI patients in a hospital,and its resistance to commonly used antibiotics is high.The occurrence of bloodstream infection of ESBLs-producing Escherichia coli is related to the patient's age,the number of days in hospital,and the use of third-generation cephalosporins in the past 3 months.

关 键 词：血流感染 产超广谱β内酰胺酶大肠埃希菌 耐药特征 危险因素 

分 类 号：R446.5[医药卫生—诊断学]