基于阴阳学说探讨小胶质细胞极化在缺血性卒中神经炎症治疗中的应用  

Investigate application of microglial polarization in treatment of neuroinflammation in ischemic stroke based on theory of Yin and Yang

作　　者：李飞亚 颜思阳 李中[1] 何孟豪 周德生[1] 马强 刘利娟[1] LI Feiya;YAN Siyang;LI Zhong;HE Menghao;ZHOU Desheng;MA Qiang;LIU Lijuan(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《陕西中医》2024年第11期1521-1524,1537,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(82104766);湖南省自然科学基金资助项目(2024JJ5313,2024JJ6358);湖南省级财政中医药项目名院工程院内优势病种项目[RSK-010-13(006-09)];长沙市自然科学基金资助项目(KQ2208202);湖南中医药大学校级科研基金资助项目(2022XYLH016)。

摘　　要：缺血性卒中(IS)在中医属于“中风”范畴,其核心病机为脏腑阴阳失调、气血逆乱。小胶质细胞极化及其介导的神经炎症贯穿IS整个病理过程,是IS的关键病理机制。M1/M2型小胶质细胞比例失衡是IS后炎症反应过度、神经损伤加剧的重要原因。小胶质细胞极化与中医阴阳学说的“对立制约”“相互转化”等相契合。本研究将小胶质细胞极化与阴阳学说联系,探讨在阴阳学说指导下中医药调控小胶质细胞极化治疗IS,为阴阳学说的微观化、现代化以及IS的中医药防治提供参考。Ischemic stroke belongs to category of stroke in traditional Chinese medicine.Its core mechanism was imbalance of Yin and Yang and rebellion of Qi and blood.Microglia polarization and neuroinflammation run through the whole pathological process of ischemic stroke,which was the key pathological mechanism of ischemic stroke.The imbalance of M1-type microglia and M2-type microglia was an important cause of excessive inflammation and aggravated nerve injury after ischemic stroke.Meanwhile,microglia polarization was compatible connotation of Yin and Yang opposition,inter-transformation in theory of Yin and Yang.Accordingly,this paper links microglia polarization with the theory of Yin and Yang,explores the use of traditional Chinese medicine to regulate microglia polarization under guidance of Yin and Yang theory for the treatment of ischemic stroke,in order to provide reference for the microcosm and modernization of the theory of Yinyang and the treatment of ischemic stroke by traditional Chinese medicine.

关 键 词：缺血性卒中 阴阳学说 小胶质细胞 神经炎症 阴平阳秘 

分 类 号：R255.2[医药卫生—中医内科学]