安神解郁汤加减联合头针治疗脑卒中后抑郁临床研究  

Clinical study on Anshen Jieyu decoction combined with head acupuncture in treatment of post-stroke depression

作　　者：范海霞 崔君平 李佳明 王俊[1] FAN Haixia;CUI Junping;LI Jiaming;WANG Jun(Qingdao Hiser Hospital Affiliated of Qingdao University,Qingdao Traditional Chinese Medicine Hospital,Qingdao 266000,China)

机构地区：[1]青岛大学附属青岛市海慈医院青岛市中医医院,山东青岛266000 [2]青岛市红岛人民医院,山东青岛266112

出　　处：《陕西中医》2024年第11期1561-1564,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技项目(M-2023081)。

摘　　要：目的:探究安神解郁汤加减联合头针治疗脑卒中后抑郁(PSD)疗效。方法:采用随机数字表法将126例PSD患者分为观察组、对照组,各63例。对照组接受常规西医治疗,观察组给予安神解郁汤加减联合头针治疗。比较两组临床疗效、中医证候积分、微小核糖核酸26b(miR-26b)、微小核糖核酸26b(miR-30a-5p)相对表达量、抑郁症状及神经功能缺损程度。结果:观察组总有效率高于对照组(P<0.05)。观察组患者中医证候积分、汉密尔顿抑郁量表(HAMD)、神经功能缺损评分(NIHSS)低于对照组(均P<0.05)。治疗前后两组miR-26b、miR-30a-5p相对表达量组内、组间比较,差异无统计学意义(均P>0.05)。结论:安神解郁汤加减联合头针治疗PSD患者能有效提高疗效,改善临床症状,减轻抑郁和神经功能缺损症状,但对miR-26b、miR-30a-5p相对表达量影响较小。Objective:To explore effect of modified Anshen Jieyu decoction combined with scalp acupuncture on patients with post-stroke depression(PSD).Methods:Using random number table method,126 patients with PSD were assigned to observation group and control group,63 cases in each group.The control group were given conventional western medicine treatment and the observation group treated with modified Anshen Jieyu decoction combined with scalp acupuncture.Clinical efficacy,TCM symptom scores,relative expression levels of micro ribonucleic acid-26b(miR-26b)micro ribonucleic acid-30a-5p(miR-30a-5p),depressive symptoms and degree of neurological impairment were compared between the two groups.Results:The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).TCM syndrome scores,HAMD scores and NIHSS scores were significantly lower than those in the control group(all P<0.05).There was no significant difference in the relative expression levels of miR-26b and miR-30a-5p within the group or between the groups before and after treatment,difference not statistically significant(all P>0.05).Conclusion:Modified Anshen Jieyu decoction combined with scalp acupuncture can effectively improve therapeutic effect on patients with PSD,improve clinical symptoms,and significantly alleviate symptoms of depression and neurological impairment,with little influence on relative expression levels of miR-26b and miR-30a-5p.

关 键 词：脑卒中 抑郁 安神解郁汤 头针 微小核糖核酸26b 微小核糖核酸30a-5p 

分 类 号：R255.2[医药卫生—中医内科学]