常用肺癌血清生物标志物与中年人群外周动脉硬化的相关性研究  

Association Between Common Serum Biomarkers of Lung Cancer and Peripheral Arterial Stiffness in Middle-Aged People

作　　者：李芸[1] 辜建伟[1,2] 杨丹 杨云凤[1] 刘菊华[1] Li Yun;Gu Jianwei;Yang Dan(Health Management Center,Health Management Research Laboratory,Geriatrics Department,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000;Gansu University of Chinese Medicine School of Traditional Chinese and Western Medicine,Lanzhou,Gansu 73000,China.)

机构地区：[1]川北医学院附属医院健康管理中心,健康管理研究室,老年科,四川南充637000 [2]甘肃中医药大学中西医结合学院,甘肃兰州730000

出　　处：《四川医学》2024年第10期1089-1095,共7页Sichuan Medical Journal

基　　金：四川省医学会静脉栓塞栓塞症防治(恒瑞)专项科研课题(编号:2019HR42);2021年川北医学院附属医院院级课题(编号:2021JC038)。

摘　　要：目的研究常用血清肺癌生物标志物与中年人群外周动脉硬化的相关性。方法选取2022年1月至2022年12月于我院健康管理中心进行常规体检的3563例中年人群为研究对象,收集一般临床资料、生化及炎症指标以及常用肺癌血清生物标志物,通过臂-踝脉搏波传导速度(baPWV)评估外周动脉硬化,根据baPWV数值,将研究人群分为对照组(n=1895)和外周动脉硬化组(n=1668)。统计分析常用肺癌血清生物标志物与baPWV的相关性。结果①外周动脉硬化组血清癌胚抗原(CEA)、神经特异性烯醇化酶(NSE),细胞角蛋白19片段(CYFRA 21-1)均显著高于对照组(P<0.001),鳞状细胞癌相关抗原(SCCA)及胃泌素释放肽前体(ProGRP)两组比较差异无统计学意义(P>0.05)。②血清CEA、NSE、CYFRA 21-1、ProGRP与baPWV呈正相关,多重线性回归分析校正其他危险因素后,血清CEA(β=30.58,P=0.03),NSE(β=8.24,P=0.03)为baPWV的独立危险因素。③ROC曲线分析CEA(1.22μg/L)及NSE(14.36μg/L)诊断外周动脉硬化的敏感度及特异度分别为57.2%,72.7及72.6%,56.3%。结论在中年人群中,血清CEA及NSE与baPWV呈正相关,是外周动脉硬化的独立危险因素,可能参与了外周动脉硬化的发生及发展。Objective To investigate the association between common serum biomarkers of lung cancer and peripheral arterial stiffness in middle-aged people.Methods From January 2022 to December 2022,total 3563 middle-aged people who underwent routine physical examination in the health management department of our hospital were enrolled in the study.General clinical data,biochemical parameters,inflammatory indicators and common serum biomarkers for lung cancer were collected,peripheral arterial stiffness was assessed by brachial ankle pulse wave velocity(baPWV),subjects were into control group(n=1895)and peripheral arterial stiffness group(n=1668)according to baPWV,the correlation between baPWV and common serum biomarkers of lung cancer was analyzed.Results①Serum Carcinoembryonic antigen(CEA),Neuron-specific enolase(NSE)and Cytokeratin-19 fragment(CYFRA 21-1)in peripheral arterial stiffness group was significantly higher than that of control group(P<0.001),squamous cell carcinoma antigen(SCCA)and pro-gastrin-releasing peptide precursor(ProGRP)showed no significant different between the two groups(P>0.05).②Serum CEA,NSE,CYFRA 21-1 and ProGRP were positively related with baPWV.After adjustment for other risk factors by multiple linear regression analysis,serum CEA(β=30.58,P=0.03)and NSE(β=8.24,P=0.03)were still independent risk factors of baPWV.③The sensitivity and specificity of CEA(1.22μg/L),NSE(14.36μg/L)in diagnosis of peripheral arterial stiffness were 57.2%,72.7 and 72.6%,56.3%,respectively.Conclusion In middle-aged people,serum CEA and NSE positively related with baPWV,were independent risk factors of peripheral arterial stiffness.

关 键 词：外周动脉硬化 癌胚抗原 神经特异性烯醇化酶 中年人群 

分 类 号：R543.5[医药卫生—心血管疾病]