阿司匹林联合替格瑞洛对不稳定型心绞痛的疗效及血清IL-6、Bip和CHOP水平的影响  

Therapeutic effect of aspirin combined with ticagrelor on unstable angina pectoris and its effect on serum IL-6,Bip and CHOP levels

作　　者：金鑫 唐成玥 陈安芳 JIN Xin;TANG Cheng-yue;CHEN An-fang(Department of Cardiology,Chengdu Shuangliu District First People's Hospital,Chengdu,Sichuan,610000,China)

机构地区：[1]成都市双流区第一人民医院心血管内科,四川成都610000

出　　处：《心血管康复医学杂志》2024年第5期585-589,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究阿司匹林联合替格瑞洛对不稳定型心绞痛(UAP)的疗效及血清白细胞介素-6(IL-6)、免疫球蛋白结合蛋白(Bip)和C/EBP同源蛋白(CHOP)水平的影响。方法:选择2021年1月至2021年12月成都市双流区第一人民医院收治的UAP患者120例,按照随机数字表法均分为联合治疗组(阿司匹林联合替格瑞洛治疗)和阿司匹林组(阿司匹林治疗)。治疗90d后,比较两组治疗的总有效率,治疗前后心排量(CO)、每搏量(SV)、左室射血分数(LVEF)、心绞痛频率、持续时间以及血清IL-6、Bip和CHOP水平,及不良反应发生率。结果:联合治疗组总有效率显著高于阿司匹林组(95.00%比81.67%,P=0.023)。治疗后,与阿司匹林组比较,联合治疗组CO[(4.79±0.95)L/min比(5.27±1.05)L/min]、SV[(52.32±5.25)ml比(56.53±4.78)ml]、LVEF[(48.73±4.41)%比(54.89±4.77)%]均显著升高,心绞痛频率[(3.27±0.75)次/周比(2.23±0.73)次/周]、心绞痛持续时间[(5.42±0.79)min/次比(3.51±0.66)min/次]以及血清IL-6[(13.49±1.41)μg/L比(6.70±0.84)μg/L]、Bip[(24.50±1.41)μg/L比(7.45±0.58)μg/L]和CHOP[(35.56±2.69)μg/L比(16.66±2.55)μg/L]水平均显著降低(P<0.05或<0.01)。两组不良反应发生率无显著差异(P=0.752)。结论:阿司匹林联合替格瑞洛治疗不稳定型心绞痛患者,疗效确切,可显著改善心功能,降低机体炎症反应和内质网应激状态。Objective:To study therapeutic effect of aspirin combined with ticagrelor on unstable angina pectoris(UAP)and its effect on serum levels of interleukin-6(IL-6),binding immunoglobin protein(Bip)and C/EBP homologous protein(CHOP).Methods:A total of 120 UAP patients who were treated in Chengdu Shuangliu District First People's Hospital between January 2021 and December 2021 were selected.According to random number table,they were equally divided into combined treatment group(aspirin combined ticagrelor therapy)and aspirin group(aspirin therapy).After 90d treatment,total effective rate,cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF),frequency and duration of angina,serum levels of IL-6,Bip and CHOP before and after treatment were compared between two groups,as well as incidence of adverse reaction.Results:The total effective rate in combined treatment group was significantly higher than that of aspirin group(95.00%vs.81.67%,P=0.023).Compared with patients in aspirin group after treatment,patients in combined treatment group had significant higher CO[(4.79±0.95)L/min vs.(5.27±1.05)L/min],SV[(52.32±5.25)ml vs.(56.53±4.78)ml]and LVEF[(48.73±4.41)%vs.(54.89±4.77)%],and significant lower frequency[(3.27±0.75)times/week vs.(2.23±0.73)times/week]and duration of angina[(5.42±0.79)min/time vs.(3.51±0.66)min/time],and serum levels of IL-6[(13.49±1.41)μg/L vs.(6.70±0.84)μg/L],Bip[(24.50±1.41)μg/L vs.(7.45±0.58)μg/L]and CHOP[(35.56±2.69)μg/L vs.(16.66±2.55)μg/L](P<0.05 or<0.01).There was no significant difference in incidence of adverse reactions between two groups(P=0.752).Conclusion:Aspirin combined with ticagrelor possesses obvious curative effect in treatment of patients with unstable angina pectoris.It can significantly improve cardiac function,reduce the inflammatory response and endoplasmic reticulum stress in these patients.

关 键 词：心绞痛 不稳定型 阿司匹林 替格瑞洛 炎症 内质网应激 

分 类 号：R541.4[医药卫生—心血管疾病]