红花黄色素注射液联合前列地尔治疗对冠状动脉旁路移植术后患者的影响  

Effect of safflower yellow pigment injection combined with alprostadil on patients after coronary artery bypass grafting

作　　者：张新花 任春梅[1] 姜丽杰[1] 杨伟光 苏红玲[1] 赵竞余[1] ZHANG Xin-hua;REN Chun-mei;JIANG Li-jie;YANG Wei-guang;SU Hong-ling;ZHAO Jing-yu(Department of Cardiovascular Surgery,Handan Central Hospital,Handan,Hebei,056002,China)

机构地区：[1]邯郸市中心医院心血管外科,河北邯郸056002

出　　处：《心血管康复医学杂志》2024年第5期590-593,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨红花黄色素注射液联合前列地尔治疗对冠状动脉旁路移植术(CABG)后患者的影响。方法:选择2018年9月~2020年9月在邯郸市中心医院心血管外科行CABG的冠心病患者92例,按入院先后顺序,分为对照组(2018年9月~2019年9月,CABG后给予常规治疗+前列地尔)和研究组(2019年10月~2020年9月,在对照组基础上给予红花黄色素注射液),各46例,均治疗28d。停药3d后,比较两组疗效、心功能指标、心肌酶谱四项、围术期观察指标的变化。结果:停药3d后,与对照组比较,研究组临床总有效率(73.9%比91.3%)、左心室射血分数(LVEF)[(55.77±4.48)%比(62.18±4.21)%]均显著提高(P=0.028、<0.001);左心房内径(LAD)[(36.83±3.45)mm比(32.09±3.23)mm]、左心室舒张末期内径(LVEDd)[(49.04±4.65)mm比(43.83±5.24)mm]、肌酸激酶(CK)[(125.13±14.21)U/L比(62.56±8.42)U/L]、乳酸脱氢酶(LDH)[(203.58±31.63)U/L比(156.07±22.26)U/L]、天冬氨酸氨基转移酶(AST)[(44.25±12.98)U/L比(35.41±12.37)U/L]、肌酸激酶同工酶(CK-MB)[(28.11±9.84)U/L比(17.59±7.41)U/L]水平显著降低(P均<0.001)。结论:红花黄色素注射液联合前列地尔可提升CABG后疗效,改善患者心功能,减轻心肌损伤。Objective:To investigate the effect of safflower yellow pigment injection combined with alprostadil on patients after coronary artery bypass grafting(CABG).Methods:A total of 92 patients with coronary heart disease who received CABG in Department of Cardiovascular Surgery,Handan Central Hospital between September 2018 and September 2020 were selected.According to order of admission,they were divided into control group(n=46,from September 2018 to September 2019,routine therapy+alprostadil after CABG)and study group(n=46,from October 2019 to September 2020,safflower yellow pigment injection based on control group),both groups were treated for 28d.On 3d after drug withdrawal,therapeutic effect,cardiac function indexes,four myocardial enzyme spectrum and perioperative indexes were compared between two groups.Results:On 3d after drug withdrawal,compared with control group,patients in study group had significant higher total effective rate(73.9%vs.91.3%),left ventricular ejection fraction(LVEF)[(55.77±4.48)%vs.(62.18±4.21)%](P=0.028,<0.001),and significant lower left atrial diameter(LAD)[(36.83±3.45)mm vs.(32.09±3.23)mm],left ventricular end-diastolic diameter(LVEDd)[(49.04±4.65)mm vs.(43.83±5.24)mm],levels of creatine kinase(CK)[(125.13±14.21)U/L vs.(62.56±8.42)U/L],lactate dehydrogenase(LDH)[(203.58±31.63)U/L vs.(156.07±22.26)U/L],aspartate aminotransferase(AST)[(44.25±12.98)U/L vs.(35.41±12.37)U/L]and creatine kinase isoenzyme MB(CK-MB)[(28.11±9.84)U/L vs.(17.59±7.41)U/L](P<0.001 all).Conclusion:The combination of safflower yellow pigment injection and alprostadil can improve the therapeutic effect and heart function,and reduce myocardial injury in patients after CABG.

关 键 词：冠心病 冠状动脉旁路移植术 非体外循环 前列地尔 

分 类 号：R541.4[医药卫生—心血管疾病]