替罗非班药物利用评价标准的建立与应用  

Establishment and Application of Drug Use Evaluation Standard of Tirofiban

作　　者：吴孝娴 毛胤俊 伍福临 王航[2,3] WU Xiao-xian;MAO Yin-jun;WU Fu-lin;WANG Hang(Department of Pharmacy,Xianyou County General Hospital,Putian 351200,China;Department of Pharmacy,the First Affiliated Hospital of Fujian Medical University,Fuzhou 35005,China;Department of Pharmacy,National Regional Medical Center,Binhai Campus of the First Affiliated Hospital,Fujian Medical University,Fujian Province,Changle 350212,China;Department of Pharmacy,Fujian Medical University,Fuzhou 350003,China)

机构地区：[1]福建省仙游县总医院药剂科,福建莆田351200 [2]福建医科大学附属第一医院药学部,福建福州350005 [3]福建医科大学附属第一医院滨海院区国家区域医疗中心药学部,福建长乐350212 [4]福建医科大学药学院,福建福州350000

出　　处：《海峡药学》2024年第9期77-82,共6页Strait Pharmaceutical Journal

摘　　要：目的建立替罗非班药物利用评价(Drug use evaluation,DUE)标准,为临床合理应用替罗非班提供参考。方法根据替罗非班说明书内容,结合相关指南和文献,经过临床和药学专家讨论,建立替罗非班DUE标准。标准内容包括用药指征、用药过程和用药结果三个方面,对福建医科大学附属第一医院2022年1月~2022年6月使用替罗非班的住院患者病历采用回顾性调查的方法进行评价。结果本次共收集病历信息133份,使用替罗非班的合理率为46.62%,不合理使用情况主要是超说明书用药(53.38%)。结论替罗非班DUE标准有较强的科学性、实用性和可行性,提示对药品说明书的修改迫在眉睫。OBJECTIVE The drug use evaluation(DUE)criteria of Tirofiban w as established to provide reference for rational clinical application of Tirofib an.METHODS According to the contents of the tirofiban specific ation,combined with relevant guidelines and literature,the Tirofiban DUE stand ard was established after discussion by clinical and pharmaceutical experts.The standard contents include three aspects of medication indication,medication pr ocess and medication result.Finally,the medical records of hospitalized patien ts receiving Tirofiban in the First Affiliated Hospital of Fujian Medical Univer sity from January 2022 to June 2022 were evaluated by retrospective investigatio n.RESULTS A total of 133 medical records were collected.The s urvey results showed that the rational rate of using Tirofiban was 46.62%,and the irrational use was mainly off-label drug use(53.38%).CONCLUSION The Tirofiban DUE standard can be used as the criterion for evaluating rational drug use in clinic and also as the guide for clinical drug use in medi cal and health institutions.

关 键 词：替罗非班 药物利用评价标准 专家咨询法 合理用药 

分 类 号：R969.4[医药卫生—药理学]