活血化瘀药对不稳定型心绞痛患者PAI-1、t-PA影响的Meta分析  

Effect of Blood-activating/Stasis-resolving Chinese Herbal Drugson PAI-1 and t-PA in Patients with Unstable Angina:a Meta-analysis

作　　者：张松青[1] 刘悦 张瑜[1] 游鹏程[1] ZHANG Song-qing;LIU Yue;ZHANG Yu;YOU Peng-cheng(The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350003,China;College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350008,China)

机构地区：[1]福建中医药大学附属第二人民医院药学部,福建福州350003 [2]福建中医药大学药学院,福建福州350008

出　　处：《海峡药学》2024年第9期88-94,共7页Strait Pharmaceutical Journal

摘　　要：目的探讨活血化瘀药对不稳定型心绞痛(Unstable angina,UA)患者纤溶酶原激活物抑制物(Plasminogen activator inhibitor-1,PAI-1)、组织型纤溶酶原激活剂(Tissue-type plasminogen activator,t-PA)水平的影响,进而评价活血化瘀药对不稳定型心绞痛患者临床疗效,从而为临床预防治疗不稳定型心绞痛提供依据。方法通过检索PubMed、EMbase、The Cochrane Library、Web of Science、ClinicalTrials.gov、万方数据和中国知网数据库,收集活血化瘀药联合西医常规治疗UA的随机对照试验(RCT)文献,采用RevMan 5.4软件进行Meta分析。结果共纳入22项研究,涉及1998例研究对象。Meta分析结果显示,与西药相比,联用活血化瘀中药可以进一步降低UA患者血清PAI-1水平[SMD=-1.96,95%CI(-2.50,-1.43)],Z=7.18,P<0.00001,升高UA患者t-PA水平[SMD=0.55,95%CI(0.41,0.69)],Z=7.85,P<0.00001。结论与常规西药治疗相比,联用活血化瘀药可进一步降低UA患者体内PAI-1水平、升高t-PA水平,改善患者纤溶活性。OBJECTIVE To explore the effect of blood-activating/stasis-re solving Chinese herbal drugs on the levels of PAI-1 and t-PA in patients with unstable angina pectoris(UA),and to evaluate the clinical efficacy of blood-activa ting/stasis-resolving Chinese herbal drugs on UA,to provide references for the tr eatment strategy of UA patients.METHODS PubMed,EMbase,The Co chrane Library,Web of Science,ClinicalTrials.gov,WanFang Data and CNKI datab ases were electronically searched to collect randomized controlled trials(RCTs)that reported blood-activating/stasis-resolving Chinese herbal drugs therapy f or UA combined with conventional Western treatment.Meta-analysis was then perf ormed using RevMan 5.4 software.RESULTS A total of 22 studies were included,involving 1998 study subjects.Meta analysis results showed that compared with conventional Western medicine,the combination of traditional Chi nese medicine for promoting blood circulation and resolving stasis can reduce se rum PAI-1 levels in UA patients〔SMD=-1.96,95%CI(-2.50,-1.43)〕,Z=7.18,P<0.00001,and increase t-PA levels in UA patients〔SMD=0.55,95%CI(0.41,0.69)〕,Z=7.85,P<0.00001.CONCLU SION Compared with conventional Western treatment,the combination of a ctivating blood circulation and removing blood stasis can further reduce the lev el of PAI-1 in UA patients,increase the level of t-PA,improve the fibrinolyt ic activity of patients.

关 键 词：活血化瘀 不稳定型心绞痛 PAI-1 META分析 

分 类 号：R969.4[医药卫生—药理学]