经直肠多模态超声联合血清学指标评估前列腺癌新辅助内分泌治疗疗效  

Efficacy of Neoadjuvant Hormone Therapy for Prostate Cancer Assessed by Transrectal Multimodal Ultrasound Combined with Serological Indices

作　　者：刘和洋 刘倩 红华 高慧敏 冯媛 Liu Heyang;Liu Qian;Hong Hua;Gao Huimin;Feng Yuan(Graduate School of Baotou Medical College,Baotou,Inner Mongolia 014040,China;Department of Ultrasound Medicine,Inner Mongolia Autonomous Region People's Hospital,Huhhot O1oo17,China)

机构地区：[1]包头医学院研究生学院,内蒙古包头市014040 [2]内蒙古自治区人民医院超声医学科,呼和浩特市010017

出　　处：《中国超声医学杂志》2024年第10期1131-1135,共5页Chinese Journal of Ultrasound in Medicine

基　　金：内蒙古自治区关键技术攻关计划项目(No.2019GG096、2019GG101)。

摘　　要：目的探讨经直肠多模态超声联合血清学指标在前列腺癌新辅助内分泌治疗疗效评估中的价值。方法收集30例病理证实为前列腺癌并接受新辅助内分泌治疗的治疗前后各周期多模态超声参数及血清前列腺特异度抗原、睾酮值,比较治疗前及治疗后3、6、9个月多模态超声及血清学参数的差异,各指标变化量与前列腺特异度抗原(PSA)的相关性采用Spearman相关分析。结果治疗后不同周期的血清总前列腺特异度抗原(TPSA)、游离前列腺特异度抗原(FPSA)、前列腺特异度抗原密度(PSAD)、睾酮相对于治疗前显著降低;治疗后各周期的多模态超声参数相对于治疗前差异均有统计学意义(P<0.05)。相关分析显示,治疗后各周期体积、峰值强度(PI)、到达时间(ATm)变化量同TPSA变化量间存在相关性;治疗后第3、第6个月PI变化值同PSAD变化值相关(P<0.05)。结论经直肠多模态超声参数在前列腺癌新辅助内分泌治疗后不同时间发生变化,且造影参数与PSA间存在相关性。多模态超声可作为前列腺癌疗效监测指标PSA的影像补充,为临床疗效评估提供帮助。Objective To explore the value of transrectal multimodal ultrasound combined with serological indexes in evaluating the efficacy of neoadjuvant hormone therapy(NHT)for prostate cancer(PCa).Methods To collect multimodal ultrasound parameters and serum prostate-specific antigen(PSA)and testosterone values of 30 cases with pathologically confirmed prostate cancer who received NHT before and after the treatment,to compare the differences of the multimodal ultrasound and serological parameters before NHT and at the third,sixth,and ninth month post therapy,and the correlation of the changes of each index with PSA was analysed by Spearman's correlation analysis.Results Serum total PSA(TPSA),free PSA(FPSA),prostate specific antigen density(PSAD),and testosterone were significantly lower in the different cycles after treatment compared with that of pretreatment;the differences in multimodal ultrasound parameters were statistically significant in all cycles after treatment in comparison to pretreatment(P<0.05).Correlation analysis showed that there was a correlation between the changes in volume,PI,and ATm and the changes in TPSA in each cycle after treatment;and the values of the changes in PI in the third and sixth months post treatment were correlated with the changes in PSAD(P<0.05).Conclusions Transrectal multimodal ultrasound parameters changes at different times after NHT for prostate cancer,and there is a correlation between the contrast parameters and PSA.Multimodal ultrasound can be used as an imaging supplement to PSA,an indicator of prostate cancer efficacy monitoring,to help clinical efficacy assessment.

关 键 词：前列腺癌 新辅助内分泌治疗 经直肠多模态超声 PSA 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]