HIV感染者抗病毒治疗失访的艾滋病药物相关知识知晓及服药信心评价  

Evaluation of HIV⁃infected patients'knowledge about AIDS drugs and confidence in taking medicine among those who lost follow⁃up to antiviral treatment

作　　者：韦玉素 覃婉妹 谢志满[2] 乃坚业[1] 郑元甲 黄金萍[2] 董文逸[2] WEI Yusu;QIN Wanmei;XIE Zhiman;NAI Jianye;ZHENG Yuanjia;HUAGN Jinping;DONG Wenyi(Department of Pharmacy,Nanning Fourth People's Hospital,AIDS Clinical Treatment Center of Guangxi(Nanning),Nanning,Guangxi 530023,China;Department of Infectious Diseases,Nanning Fourth People's Hospital,AIDS Clinical Treatment Center of Guangxi(Nanning),Nanning,Guangxi 530023,China)

机构地区：[1]南宁市第四人民医院药剂科,广西艾滋病临床治疗中心(南宁),广西南宁530023 [2]南宁市第四人民医院感染科,广西艾滋病临床治疗中心(南宁),广西南宁530023

出　　处：《热带医学杂志》2024年第9期1312-1317,共6页Journal of Tropical Medicine

基　　金：国家自然科学基金(NSFC#81761128004);广西区卫健委自筹经费科研课题(Z20170149);南宁市人才小高地专项资金资助项目(2017032)。

摘　　要：目的评价抗病毒治疗失访HIV感染者艾滋病药物相关知识知晓和服药信心及影响因素,为减少HIV感染者失访提供有价值的参考。方法选取2021年1月-2022年12月在广西艾滋病临床治疗中心(南宁)进行抗病毒治疗后失访的112例HIV感染者为失访组,随机选取200例未失访者为对照组,采用药物相关知识评价指标评价失访组和对照组艾滋病药物相关知识(10个条目)、正确服药的信心(7个条目)。HIV感染者正确服药信心的可能影响因素性别、年龄、户籍、居住地、文化程度、工作情况、家庭月收入、出现药物不良反应信心、没有人提醒服药、药物相关知识等10项按α=0.10的水准进行单因素筛选,将单因素分析结果纳入logistic回归分析,探讨HIV感染者正确服药信心的影响因素。结果两组年龄、文化程度、出现药物不良反应信心、没有人提醒服药、药物相关知识等5个因素比较差异均有统计学意义(χ^(2)/t=-3.714、6.327、71.548、42.814、41.179,P均<0.05)。艾滋病药物相关知识中,失访组掌握程度知晓的平均比例为51.96%,低于对照组的85.45%,两组10个条目[(1)如果出现漏服,我知晓该怎么做;(2)正确服药可以降低病毒载量;(3)我知晓什么时候该服药;(4)如果我不按规定服药,这些药物可能对我不再起作用;(5)我知晓所服用的药物带来什么样的药物不良反应;(6)我知晓如何应对可能会有的药物不良反应;(7)偶尔不服药对我的身体没有好处:(8)按时服药能让人体内的药物保持稳定;(9)有些药物必须在饭前(或饭后)服用才有效果;(10)产生耐药性表示药物无法继续杀灭病毒]间差异均有统计学意义(χ^(2)=101.027、50.001、55.773、85.301、169.025、83.705、17.236、31.429、18.175、37.793,P均<0.05);其中差异最大的条目为(5)我知晓所服用药物带来什么样的药物不良反应(70.68%)。正确服药的信心中,除条目(3)其他人在场服药不方便外Objective To evaluate the knowledge of AIDS drugs and the confidence of taking AIDS drugs,and the influencing factors, and provide a valuable reference for reducing the loss of follow⁃up of HIV patients. Methods A total of112 lost patients who received antiviral treatment in AIDS Clinical Treatment Center of Guangxi(Nanning) were selected asthe lost follow ⁃ up group and 200 non ⁃lost patients were randomly selected as the control group from January 2021 toDecember 2022. The National Natural Science Foundation Sino⁃US Cooperation Project were used to evaluate the AIDS drug⁃related knowledge of the lost follow⁃up group and the control group, including the awareness rate of drug⁃related knowledgeand confidence (10 items) and the confidence of taking drugs on time (7 items). Gender, age,household register, place ofresidence, educational level, work situation, monthly family income, confidence in adverse drug reactions, no one toremind taking medicine, and knowledge related to drugs were univariate screened at the level of α=0.10, and the results ofunivariate analysis were incorporated into logistic regression analysis. The factors influencing the confidence of HIV⁃infectedpeople to take medicine correctly were evaluated. Results There were significant differences between the two groups inage, education level, confidence in adverse drug reactions, no one to remind taking medicine, and knowledge related todrugs (χ^(2)/t=-3.714, 6.327, 71.548, 42.814, 41.179;all P<0.05). In terms of knowledge about AIDS drugs, the averageproportion of knowledge in the lost follow⁃up group was 51.96%, lower than 85.45% in the control group. The two groupsshowed significant differences in 10 items of the AIDS drug knowledge [(1) I know what to do if I miss taking themedication;(2) taking the medication correctly can reduce the viral load;(3) I know when to take the medication;(4) IfI don't take my medications as prescribed, they may no longer work for me;(5) I know what kind of adverse drug reactionscaused by the drug

关 键 词：艾滋病 抗逆转录病毒治疗 艾滋病药物 相关知识 服药信心 

分 类 号：R512.91[医药卫生—内科学]