结肠运动与离子通道的研究进展  

Research Progress on Colonic Motility and Ion Channels

作　　者：李永丰 林丽 薛思梦 乔海法 LI Yongfeng;LIN Li;XUE Simeng;QIAO Haifa(Innovation Center for Combination of Acupuncture and Medicine,School of Acupuncture and Moxibustion and Massage,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China)

机构地区：[1]陕西中医药大学针灸推拿学院针药结合创新中心,陕西咸阳712046

出　　处：《现代中医药》2024年第6期24-29,共6页Modern Chinese Medicine

基　　金：陕西省教育厅项目(20JK0592)。

摘　　要：结肠运动障碍是导致肠道疾病的重要因素,且也常并发于其他器质性疾病。离子通道作为细胞膜上的一种跨膜受体蛋白,可介导离子被动流入/流出细胞,控制细胞质/细胞器内离子浓度、膜电位和细胞体积,是调控结肠运动的关键因素。文章围绕结肠运动与Ca^(2+)、Na^(+)、K^(+)、TRPV1离子通道关系进行综述,可能为高效治疗结肠疾病提供研究基础。Colonic motility disorders are an important factor leading to intestinal diseases and are often associated with other organic diseases.As a transmembrane receptor protein on the cell membrane,ion channels can mediate the passive influx/efflux of ions into/from cells,control ion concentration,membrane potential,and cell volume in the cytoplasm/organelles,and are key factors in regulating colonic motility.The article reviews the relationship between colon motility and Ca^(2+),Na^(+),K^(+),TRPV1 ion channels,which may provide a research basis for efficient treatment of colon diseases.

关 键 词：结肠运动 钙离子通道 钾离子通道 钠离子通道 TRPV1 

分 类 号：R574.62[医药卫生—消化系统]