去乙酰化酶SIRTs在帕金森病中的研究进展  

Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease

作　　者：方雪 石瑾 李海宁[1] 杨娟[1] FANG Xue;SHI Jin;LI Haining;YANG Juan(Department of Neurology,General Hospital of Ningxia Medical University,Yinchuan 750004;Department of Neurology,Helan County People's Hospital,Yinchuan 750200,China)

机构地区：[1]宁夏医科大学总医院神经内科,宁夏银川750004 [2]贺兰县人民医院神经内科,宁夏银川750200

出　　处：《基础医学与临床》2024年第11期1603-1607,共5页Basic and Clinical Medicine

基　　金：宁夏自然科学基金(2022AAC03561);宁夏回族自治区重点研发计划(2022BEG03130);宁夏医科大学校级项目(XZ2020010)。

摘　　要：Sirtuins(SIRTs)是一类依赖于NAD+的去乙酰化酶,在神经退行性疾病中,特别是在帕金森病(PD)中备受关注。Sirtuins通过调控细胞内的代谢、应激反应和DNA修复等多种生物学过程,对细胞存活和凋亡具有重要作用。在PD的发病机制中,Sirtuins发挥关键作用,与线粒体功能、氧化应激及神经元凋亡等病理生理过程紧密相关。激活Sirtuins能够减轻PD动物模型的运动障碍和神经元损伤,同时调节α-突触核蛋白(α-Syn)的聚集和清除,这是PD的病理特征之一。因此,调节Sirtuins可能成为治疗PD的潜在策略之一。Sirtuins(SIRTs),a group of NAD+dependent deacetylases,have attracted considerable attention in the field of neuro-degenerative diseases,especially Parkinson's disease(PD).They have critical impacts on cell survival and death through modulation of various biological processes,such as intracellular metabolism,stress response and DNA repair.In the pathogenesis of PD,Sirtuins play a crucial role and associated with pathophysiological processes such as mitochondrial function,oxidative stress,and neuronal apoptosis.Activation of Sirtuins alleviates dyskinesia and neuronal damage in animal models of PD and also regulates the aggregation and clearance of α-synuclein,a pathological feature of the disease.Therefore,the modulation of Sirtuins is a potential strategy for treating PD.

关 键 词：帕金森病 去乙酰化酶Sirtuins Α-突触核蛋白 

分 类 号：R33[医药卫生—人体生理学]