血清LTBP2、Ucn1、CD90水平在子宫内膜异位症诊断及病情严重程度评估中的价值  

Value of serum LTBP2,Ucn1,and CD90 levels in the diagnosis and severity assessment of endometriosis

作　　者：朱剑飞[1] 谢艳艳 ZHU Jianfei;XIE Yanyan(Department of Obstetrics and Gynecology,Yangzhou University Affiliated Hospital,Yangzhou,Jiangsu 225009,China)

机构地区：[1]扬州大学附属医院妇产科,江苏扬州225009

出　　处：《国际检验医学杂志》2024年第21期2605-2609,共5页International Journal of Laboratory Medicine

基　　金：江苏省卫生健康委科研项目(20210334)。

摘　　要：目的探讨血清转化生长因子结合蛋白2(LTBP2)、尿皮质醇1(Ucn1)、抗原分化簇90(CD90)水平在子宫内膜异位症(EMT)诊断及病情严重程度评估中的价值。方法选取2020年1月至2023年12月在该院进行诊断治疗的EMT患者103例作为实验组,按病情程度将实验组分为重度组与轻度组,另选取同期在该院体检的体检健康者82例作为对照组。采用Pearson分析血清LTBP2、Ucn1、CD90水平相关性,采用多因素Logistic回归分析影响EMT患病因素,通过受试者工作特征(ROC)曲线评价血清LTBP2、Ucn1、CD90对EMT的诊断价值。结果实验组与对照组比较,血清LTBP2、Ucn1、CD90水平呈显著升高的趋势(P<0.05)。实验组血清LTBP2、Ucn1、CD90之间呈正相关(r=0.377、0.344、0.246,P<0.001、<0.001、=0.012)。轻度组与重度组血清LTBP2、Ucn1、CD90水平均显著高于对照组患者,轻度组患者血清LTBP2、Ucn1、CD90水平显著低于重度组患者,差异有统计学意义(P<0.05)。实验组白细胞介素(IL)-4水平低于对照组,而经期疼痛及盆腔手术史占比高于对照组,差异有统计学意义(P<0.05)。血清LTBP2、Ucn1、CD90水平、经期疼痛、盆腔手术史是发生EMT的危险因素(P<0.05),IL-4水平是发生EMT的保护因素(P<0.05)。血清LTBP2、Ucn1、CD90及三者联合对EMT诊断的曲线下面积为0.788、0.801、0.810、0.916,灵敏度为63.11%、63.11%、62.14%、84.47%,三者联合(Z_(LTBP2-三者联合)=4.054、P<0.001,Z_(Ucn1-三者联合)=3.966、P<0.001,Z_(CD90-三者联合)=4.193、P<0.001)对EMT诊断价值更高。结论EMT病情程度较重者血清LTBP2、Ucn1、CD90水平较高,血清LTBP2、Ucn1、CD90联合对EMT具有一定诊断价值。Objective To investigate the value of serum latent transforming growth factor beta binding protein 2(LTBP2),urocortin 1(Ucn1),and cluster of differentiation 90(CD90)levels in the diagnosis and severity assessment of endometriosis(EMT).Methods A total of 103 EMT patients who underwent diagnosis and treatment in the hospital from January 2020 to December 2023 were selected as the experimental group.The experimental group was separated into a severe group and a mild group.In addition,82 healthy individuals who underwent physical examinations in the hospital were selected as the control group.The correlation analysis of serum LTBP2,Ucn1,and CD90 levels was performed using Pearson.Multivariate Logistic regression was applied to analyze the influencing factors of EMT.Receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of serum LTBP2,Ucn1,and CD90 for EMT.Results Compared with the control group,the serum levels of LTBP2,Ucn1,and CD90 in the experimental group showed an increase trend(P<0.05).There was positive correlation between serum LTBP2,Ucn1,and CD90 in the experimental group(r=0.377,0.344,0.246,P<0.001,<0.001,=0.012).The serum levels of LTBP2,Ucn1,and CD90 were significantly higher in the mild group and the severe group than those in the control group(P<0.05).The serum levels of LTBP2,Ucn1,and CD90 in the mild group were obviously lower than those in the severe group,and the differences were statistically significant(P<0.05).The interleukin(IL)-4 level in the experimental group was lower than that in the control group,and the proportions of menstrual pain and pelvic surgery were higher than those in the control group,and the differences were statistically significant(P<0.05).Serum levels of LTBP2,Ucn1,and CD90,menstrual pain,and a history of pelvic surgery were risk factors for EMT(P<0.05),while IL-4 level was a protective factor for EMT(P<0.05).The area under the curve of serum LTBP2,Ucn1,CD90,and their combination for EMT diagnosis was 0.788,0.801,0.810,and 0.916,with sensiti

关 键 词：子宫内膜异位症 转化生长因子结合蛋白2 尿皮质醇1 抗原分化簇90 诊断 病情严重程度 

分 类 号：R711.71[医药卫生—妇产科学]