A plausible pathway to prebiotic peptides via amino acid amides on the primordial Earth  

作　　者：DingWei Gan XiangMin Lei RenWu Zhou SongSen Fu Jing Sun RuSen Zhou Kostya(Ken)Ostrikov YuFen Zhao JianXi Ying 

机构地区：[1]Institute of Drug Discovery Technology,Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences,Ningbo University,Ningbo Zhejiang 315211,China [2]School of Electrical Engineering,Xi’an Jiaotong University,Xi’an 710049,China [3]College of Food Science and Engineering,Tianjin University of Science and Technology,Tianjin 300457,China [4]School of Chemistry and Physics,Queensland University of Technology,Brisbane,QLD 4000,Australia [5]Department of Chemical Biology,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China

出　　处：《Earth and Planetary Physics》2024年第6期868-877,共10页地球与行星物理（英文版）

基　　金：National Natural Science Foundation of China(Nos.42388101,92256203,and 42003062);Fundamental Research Funds for the Provincial Universities of Zhejiang(No.SJLY2023007);Technology and Engineering Center for Space Utilization,Chinese Academy of Sciences(No.YYWT-0901-EXP-16);Ningbo Top Talent Project(No.215-432094250).

摘　　要：The prebiotic synthesis of peptides prior to ribosome-catalyzed processes remains an enigma.The synthesis of abiotic peptides from amino acids(AAs)is primarily constrained by high activation energies and unfavorable thermodynamics,necessitating the identification of plausible prebiotic alternatives for synthesizing prebiotic peptides.Here we present a plausible pathway to the formation of prebiotic peptides,wherein oligopeptides,oligopeptide amides,and cyclic oligopeptides can be directly synthesized from amino acid amides(AA-NH2)under wet–dry cycle conditions without the need for any enhancers.The subsequent investigation revealed that AA-NH2 demonstrated more favorable thermodynamic reaction effects than AAs in peptide formation.In contrast to the polymerization of AAs,the process of peptide formation through the polymerization of AA-NH2 was significantly simplified.Additionally,AA-NH2 was discovered to function as a“bridge”for the formation of peptides from AAs,thereby facilitating their participation in the synthesis of intricate peptide structures.On the basis of these findings,a plausible mechanism for the prebiotic origin network of peptides under primordial Earth conditions has been proposed.Overall,this research presents a plausible pathway for the generation of prebiotic peptides and peptide libraries within prebiotic environments.

关 键 词：prebiotic chemistry origin of life chemical evolution PEPTIDE 

分 类 号：O629.72[理学—有机化学]