苍附导痰汤治疗痰湿型多囊卵巢综合征的作用机制及临床应用研究进展  

Research progress on action mechanisms and clinical application of Cangfu Daotan Decoction in treatment of polycystic ovary syndrome with phlegm-dampness type

作　　者：李婧怡 陈静[1] 王莹莹 徐紫薇 李佾晟 宁婧 LI Jingyi;CHEN Jing;WANG Yingying;XU Ziwei;LI Yisheng;NING Jing(Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《上海中医药大学学报》2024年第5期101-108,共8页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市中医医院未来计划-中医药传承人才培育项目(WLJH2021ZY-MZY035);上海市中医医院未来计划-中医药科技发展项目(WL-YJXYS-2021002K)。

摘　　要：多囊卵巢综合征(PCOS)是绝经前妇女最常见的内分泌和代谢紊乱的疾病之一,苍附导痰汤是治疗痰湿型PCOS的常用方,其疗效较佳。通过梳理相关文献发现,苍附导痰汤可通过调节内分泌和糖脂代谢、减少卵巢颗粒细胞自噬和凋亡、调控相关信号通路和氧化应激等,来干预治疗PCOS。此外,在临床中,单独使用苍附导痰汤或联合西药或联合外治法,均可明显改善痰湿型PCOS患者的临床症状及并发症,值得推广应用。通过分析苍附导痰汤治疗PCOS的研究现状,为该方的深入研究和临床应用提供有力的文献支撑。Polycystic ovary syndrome(PCOS)is one of the most common diseases of endocrine and metabolic disorders in premenopausal women,and Cangfu Daotan Decoction is a commonly used formula for treating PCOS of phlegm-dampness type with better efficacy.Through combing the relevant literatures,it was found that Cangfu Daotan Decoction can treat the PCOS by regulating endocrine and glucose-lipid metabolism,reducing autophagy and apoptosis of ovarian granulosa cells,and modulating the related signaling pathways and oxidative stress,etc.In addition,Cangfu Daotan Decoction alone or in combination with western medicines or in combination with external therapies can significantly improve the clinical symptoms and complications in patients with PCOS of phlegm-dampness type in the clinic,which is worthy of popularization and application.By analyzing the current research status of Cangfu Daotan Decoction in the treatment of PCOS,this paper can provide strong literature support for the in-depth research and clinical application of this formula.

关 键 词：多囊卵巢综合征 痰湿型 苍附导痰汤 作用机制 临床应用 综述 

分 类 号：R271.9[医药卫生—中西医结合]