用于胶质母细胞瘤治疗的siRNA非病毒递送系统研究进展  

Research Progress on Non-viral Delivery Systems of siRNA for Glioblastoma Treatment

作　　者：江芷萱 贾瑞沂 丁源[1] 陆伟跃[1,2] JIANG Zhixuan;JIA Ruiyi;DING Yuan;LU Weiyue(Key Lab.of Smart Drug Delivery(Fudan University),Ministry of Education and PLA,Dept.of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 201203;Dept.of Research and Development,Shanghai Tayzen PharmLab Co.,Ltd.,Shanghai 201314)

机构地区：[1]复旦大学药学院药剂学系,智能化递药教育部及全军重点实验室(复旦大学),上海201203 [2]上海泰禛生物技术有限公司研发部,上海201314

出　　处：《中国医药工业杂志》2024年第10期1307-1317,共11页Chinese Journal of Pharmaceuticals

摘　　要：胶质母细胞瘤(GBM)是恶性程度较高的脑部肿瘤,具有高致残率、高复发率的特点。GBM经常规治疗后易复发,且耐药患者预后情况不佳。小干扰RNA(siRNA)能通过沉默特定基因、下调蛋白表达而产生疗效,可作为常规治疗的补充,进一步抑制GBM的发展进程。文章阐述了siRNA递送入脑的困境、siRNA治疗GBM的作用机制,并总结了5种用于GBM治疗的siRNA非病毒递送系统,以期为siRNA在GBM治疗中的应用研究提供参考。Glioblastoma(GBM)is a highly malignant brain tumor with high disability and recurrence rate.Conventional treatment for GBM is prone to recurrence,and the prognosis of drug-resistant patients is unfavorable.Small interfering RNA(siRNA)can generate therapeutic effects by silencing specific genes and down-regulating protein expression,and can serve as a supplement to conventional treatment by inhibiting the development process of GBM.This review elaborates on the difficulties of siRNA delivery into the brain and the mechanism of GBM treatment by siRNA.Additionally,it summarizes the application of five non-viral siRNA delivery systems for GBM treatment,in order to provide a reference for the application research of siRNA in GBM treatment.

关 键 词：胶质母细胞瘤 SIRNA 脂质纳米粒 脂质体 聚合物纳米粒 胶束 外泌体 研究进展 

分 类 号：R944.9[医药卫生—药剂学] R979.11[医药卫生—药学]