基于活性氧响应性的纳米载药系统治疗细菌感染研究进展  

Advances in the Treatment of Bacterial Infections with ROS-Responsive Nano-Drug Delivery Systems

作　　者：熊楚豫 雷志鑫 孙涛垒 XIONG Chuyu;LEI Zhixin;SUN Taolei(School of Chemistry,Chemical Engineering and Life Sciences,Wuhan University of Technology,Hubei Provincial Key Laboratory of Nanomedicine for Neurodegenerative Diseases,Wuhan 430070,China;State Key Laboratory of New Technology for Materials Composites,School of Materials,Wuhan University of Technology,Wuhan 430070,China)

机构地区：[1]武汉理工大学化学化工与生命科学学院,神经退行性疾病纳米医药湖北省重点实验室,武汉430070 [2]武汉理工大学材料学院材料复合新技术国家重点实验室,武汉430070

出　　处：《医药导报》2024年第11期1804-1812,共9页Herald of Medicine

基　　金：国家自然科学基金资助项目(32202857);国家级大学生创新训练计划创新训练项目(S202310497220);中央高校基本科研业务费专项资金资助项目(2021IVA075);教育部产学研合作协同育人项目(KGRCYJY2021005)。

摘　　要：现阶段迫切需要开发新的抗菌药物或抗菌材料来治疗耐药细菌感染性疾病,基于活性氧(ROS)响应性的纳米载药系统对于细菌感染治疗具有非常重要的意义。该文综述了聚合物类、无机物类、复合材料类ROS响应纳米载药系统,讨论了ROS响应纳米载药系统与光热治疗、光动力治疗、声动力治疗、气体治疗的协同治疗,展望了该系统治疗细菌感染性疾病的新趋向。Currently,there is an urgent need to develop new antimicrobial drugs or materials to treat drug-resistant bacterial infectious diseases.The reactive oxygen species(ROS)responsive nano-drug delivery systems hold great significance for bacterial infection treatment.This paper reviewed polymeric,inorganic,and composite ROS-responsive nano-drug delivery systems.It discussed synergistic treatment using these systems with photothermal therapy,photodynamic therapy,sonodynamic therapy,and gas therapy.It outlines new trends in these systems for bacterial infectious disease treatment.

关 键 词：纳米载药系统 细菌感染 活性氧响应 

分 类 号：R94[医药卫生—药剂学] R978[医药卫生—药学]