响应面法优化黄参肠舒洗剂的提取工艺  

Optimization of Extraction Process for Huangshen Changshu Lotion by Response Surface Methodology

作　　者：李丹[1] 万蒞 张莎莎[1] 覃娴雅 LI Dan;WAN Li;ZHANG Shasha;QIN Xianya(Department of Pharmacy,Hubei Maternal and Child Health Hospital,Wuhan 430070,China)

机构地区：[1]湖北省妇幼保健院药学部,武汉430070

出　　处：《医药导报》2024年第11期1844-1848,共5页Herald of Medicine

摘　　要：目的基于响应面法优选黄参肠舒洗剂闪式提取工艺参数。方法采用闪式提取技术,以大黄酚提取量、大黄素提取量及干膏得率综合评分为评价指标,通过响应面Design-Expert软件所提供的Box-Behnken Design程序来进行实验设计,优化建立黄参肠舒洗剂闪式提取的工艺参数,并与传统提取工艺进行比较。结果黄参肠舒洗剂闪式提取的最佳提取工艺参数为转速4000 r·min^(-1)、料液分配比1:25(g·mL^(-1))、提取时间100 s。结论所建立的黄参肠舒洗剂闪式提取工艺技术可行,与传统提取工艺比较优势明显,为黄参肠舒洗剂新的提取工艺及后续的开发提供了研究基础。Objective To optimize of flash extraction parameters for Huangshen Changshu lotion based on response surface methodology.Methods Using flash extraction technology,the comprehensive scores of the extraction amount of rhein,emodin,and dry cream yield were used as evaluation indicators.The Box Behnken Design program provided by Response Surface Design Expert software was used for experimental design to optimize the optimal process parameters for flash extraction of Huangshen Changshu lotion,and compared with traditional extraction processes.Results The optimal extraction process parameters for Huangshen Changshu lotion flash extraction are as follows:a rotational speed of 4000 r·min^(-1),a solid-liquid ratio of 1:25(g·mL^(-1)),and an extraction time of 100 s.Conclusion The flash extraction process technology for Huangshen Changshu lotion established through research is feasible and has obvious advantages compared to traditional extraction processes,providing a research foundation for new extraction processes and subsequent drug development of Huangshen Changshu lotion.

关 键 词：黄参肠舒洗剂 大黄酚 大黄素 闪式提取 响应面法 

分 类 号：R286[医药卫生—中药学] R95[医药卫生—中医学]