T2型炎症反应与鼻息肉组织重塑的研究进展  

Research progress of type 2 inflammation-related tissue remodeling in nasal polyps

作　　者：黄雨晴 孟琛 闫冰[1,2,3] 王成硕 张罗[1,2,3,4] HUANG Yuqing;MENG Chen;YAN Bing;WANG Chengshuo;ZHANG Luo(Department of Otolaryngology,Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing,100730,China;Beijing Institute of Otolaryngology,Beijing Laboratory of Allergic Diseases,Beijing Key Laboratory of Nasal Diseases,Key Laboratory of Otolaryngology Head and Neck Surgery,Ministry of Education,Capital Medical University;ResearchUnit of Diagnosis and Treatment of Chronic Nasal Diseases,Chinese Academy of Medical Sciences;Department of Allergy,Beijing TongRen Hospital,Capital Medical University)

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科、耳鼻咽喉头颈科学教育部重点实验室(首都医科大学),北京100730 [2]北京市耳鼻咽喉科研究所教育部工程中心鼻病研究北京市重点实验室 [3]中国医学科学院慢性鼻病创新单元 [4]首都医科大学附属北京同仁医院变态反应科

出　　处：《临床耳鼻咽喉头颈外科杂志》2024年第9期872-878,882,共8页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家重点研发计划(No:2022YFC2504100);国家自然科学基金(No:82025010、No:81630023、No:82171108、No:81900917、No:81870698、No:82301329);教育部长江学者创新团队(No:IRT13082);中国医学科学院医学与健康科技创新工程项目资助(No:2019-I2M-5-022);北京市科学技术委员会项目(No:Z221100007422009、No:Z211100002921057);首都卫生发展科研专项(No:CFH2022-1-1091);北京市医院管理局使命计划(No:SML20150203);北京市属医学科研院所公益发展改革试点项目(No:JYY2021-2);北京市属医院科研培育计划(No:PX2024010)。

摘　　要：慢性鼻窦炎伴鼻息肉是常见的慢性炎性疾病,伴有明显的组织重塑,其重塑机制尚不明确。研究发现T2型炎症网络在组织重塑及鼻息肉形成过程中发挥至关重要的作用,并已针对多个生物靶点开展临床试验,还有若干潜在的治疗靶点受到越来越多的关注。本文将归纳总结T2型炎症反应参与鼻息肉组织重塑的研究进展,以期为进一步探究鼻息肉组织重塑的发生机制提供思路。Chronic rhinosinusitis with nasal polyps is a common chronic inflammatory disease with significant tissue remodeling,but the mechanism of remodeling remains unclear.Studies have shown that Type(T)2 inflammatory network plays a crucial role in tissue remodeling and nasal polyp formation.Clinical trials have been carried out for several biological targets,and a number of potential therapeutic targets have received increasing attention.This paper will summarize the research progress of T2 inflammatory response involved in nasal polyp tissue remodeling to provide ideas for further exploring the mechanism of nasal polyp tissue remodeling.

关 键 词：慢性鼻窦炎伴鼻息肉 鼻息肉 T2型炎症 黏膜组织重塑 炎症因子 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]