MND1的生物学功能及在肿瘤发生发展中作用的研究进展  

The biological function of MND1 and its research progress in tumor development

作　　者：李慧清 庞振飞 刘爽[1] 李楠 LI Huiqing;PANG Zhenfei;LIU Shuang;LI Nan(School of Basic Medicine,Jiamusi University,Key Laboratory of Microecology-Immunomodulatory Network and Related Diseases,School of Basic Jiamusi University Medicine,Heilongjiang Jiamusi 154007,China)

机构地区：[1]佳木斯大学基础医学院,佳木斯大学基础医学院微生态-免疫调节网络与相关疾病重点实验室,黑龙江佳木斯154007

出　　处：《现代肿瘤医学》2024年第21期4177-4182,共6页Journal of Modern Oncology

基　　金：黑龙江省教育厅基本科研业务费基础研究(编号:2020-KYYWF-0283);口腔生物医学材料研发及个性化制造特色学科(编号:黑教联【2022】78号)。

摘　　要：细胞周期进程失控是肿瘤异常增殖的一个显著标志。细胞周期相关基因变化可引起细胞周期失调,从而导致细胞分裂不受控制,是促进肿瘤细胞生长的重要原因。若打破肿瘤细胞周期相关因子内源性动态平衡,可能会导致细胞发生异常增殖而形成肿瘤。减数分裂因子可能是肿瘤治疗和生物监测的重要靶点。目前对于减数分裂核分裂蛋白1同系物(meiotic nuclear divisions 1,MND1)的研究较少,但关于MND1在肿瘤发展中的重要作用的报道日益增多,MND1在多种肿瘤中的异常表达与肿瘤的发生发展密切相关。该文从MND1在肿瘤中的生物学功能、MND1与肿瘤发生发展之间的关系等方面的研究进展进行综述,有助于更加深入地分析该基因在肿瘤中的作用机制。Uncontrolled cell cycle progression is a significant sign of abnormal tumor proliferation.Cell cycle-related gene changes can cause cell-cycle disorder,resulting in uncontrolled cell division,an essential reason for promoting tumor cell growth.Breaking the endogenous homeostasis of tumor cell cycle-related factors may lead to abnormal cell proliferation and tumor formation.The meiosis factor may be an essential target for tumor therapy and biomonitoring.Few studies have been conducted on meiotic nuclear divisions 1(MND1),but more and more reports have been reported on the critical role of MND1 in tumor development.The abnormal expression of MND1 in various tumors is closely related to the occurrence and development of tumors.In this paper,the biological function of MND1 in tumors and the relationship between MND1 and tumor development are reviewed,which is helpful to analyze further the mechanism of action of this gene in tumors.

关 键 词：减数分裂核分裂蛋白1 肿瘤 细胞周期 研究进展 

分 类 号：R730[医药卫生—肿瘤]