天麻超微粉对晕动症模型小鼠行为学的影响  

The effect of ultrafine Tianma powder on the behavior of motion sickness model mice

作　　者：朱洪日 李建湘 王召君 陈永红 ZHU Hongri;LI Jianxiang;WANG Zhaojun;CHEN Yonghong(Army Service College of Chinese People's Liberation Army,Chongqing 401331,China;Jiangsu Mingchao Food Technology Co.,Ltd.,Nanjing,Jiangsu 210016,China;Eastern Theater Center for Disease Control and Prevention,Nanjing,Jiangsu 210002,China)

机构地区：[1]中国人民解放军陆军勤务学院,重庆401331 [2]江苏名朝食品科技有限公司,江苏南京210016 [3]东部战区疾病预防控制中心,江苏南京210002

出　　处：《食品与机械》2024年第9期138-144,共7页Food and Machinery

摘　　要：[目的]解决抗眩晕药物副作用问题,开发药食同源抗晕动症的功能性食品。[方法]将50只小鼠适应性饲养7d后,分为正常组、模型组、阳性药物组、天麻H组、天麻L组,通过旋转刺激法构建小鼠晕动病模型,以天麻超微粉(天麻素含量1.05%)灌胃给药,采用晕反应指数、平衡木试验、自发活动试验等行为学指标,评估天麻对晕动症模型小鼠的治疗效果。[结果]正常组小鼠MSI值为2.11±0.59,模型组小鼠的晕反应指数极显著提高(P<0.001),表明试验动物造模成功;与模型组相比,天麻H组和天麻L组小鼠的晕反应指数降低了55.8%(P<0.01)和43.4%(P<0.05);天麻H组通过平衡木时间为(29.00±19.56)s,相比模型组显著缩短(P<0.05),其平衡木行为评分降低了33.3%(P<0.05);天麻H组和天麻L组小鼠的自发活动总路程分别增加了399.1%和326.4%,显著高于模型组小鼠的(P<0.05)。[结论]天麻超微粉对模型小鼠晕动症有缓解作用,且无不良副作用。[Objective]To solve the problem of adverse side effects of anti-vertigo drugs and to develop functional foods with the same source of medicine and food as anti-motion sickness.[Methods]After 7 days of adaptive feeding,50 mice were divided into normal group,model group,positive drug group,Gastrodia H group and Gastrodia L group,and the mouse motion sickness model was constructed by rotational stimulation method,and the ultrafine powder of Gastrodia(gastrodin content 1.05%)was administered by gavage,and the treatment effect of Gastrodia on motion sickness model mice was evaluated by behavioral indicators such as motion sickness reaction index,balance beam test and spontaneous activity test.[Results]The MSI value of mice in the normal group was 2.11±0.59,and the corona response index of the mice in the model group was significantly increased(P<0.001),indicating that the experimental animals were successfully modeled.Compared with the model group,the corona response index of Gastrodia H group and Gastrodia L group decreased by 55.8%(P<0.01)and 43.4%(P<0.05).Compared with the model group,the time of passing the balance beam in Gastrodia H group was(29.00±19.56)s,which was significantly shorter than that of the model group(P<0.05),and its balance beam behavior score was reduced by 33.3%(P<0.05).The total distance of spontaneous activity in the H and L groups increased by 399.1%and 326.4%,respectively,which was significantly higher than that in the model group(P<0.05).[Conclusion]Gastrodia ultrafine powder has a relieving effect on motion sickness in model mice,and there are no adverse side effects.

关 键 词：晕动症 天麻超微粉 抗晕动症 试验动物行为学 

分 类 号：R285.5[医药卫生—中药学]