国产和进口人促红素治疗老年患者贫血经济学分析  

Economic Analysis of Domestic and Imported Human Erythropoietin in the Treatment of Elderly Patients with Anemia

作　　者：林梅玉 郑琛 蔡柔荧 刘琴 王非 LIN Mei-yu;ZHENG Chen;CAI Rou-ying;LIU-Qin;WANG-Fei(Clinical Medicine Department of Fujian Medical University,Pharmacy Department of Fujian Provincial Geriatric Hospital,Fuzhou 350003,China)

机构地区：[1]福建医科大学临床医学部福建省老年医院药学部,福建福州350003

出　　处：《海峡药学》2024年第10期51-55,共5页Strait Pharmaceutical Journal

摘　　要：目的比较国产和进口人促红素治疗老年患者贫血的经济性,为临床选择药物提供参考。方法回顾性查阅2019年1月至2024年5月某医院老年贫血患者使用国产和进口人促红素的病历各38份,采用倾向性评分匹配后的数据进行最小成本分析两种药物治疗贫血的经济性,采用线性回归分析多种因素对效果的影响。结果匹配后患者的病例数分别是37份、33份,在性别、年龄、用药前血红蛋白、疾病方面均无统计学差异;以HGB上升≥10 g·L^(-1)统计总有效率,有效率分别为51.51%、48.65%(P>0.05),国产和进口人促红素治疗贫血的总成本分别为(389.29±77.62)元、(1884.29±554.05)元(P<0.01)。线性回归结果表明模型构建良好,各因素对效果没有存在显著性影响关系。结论与进口人促红素比较,国产人促红素在改善老年患者1个月左右住院治疗贫血临床疗效和安全性方面差异无统计学意义,短期经济性更佳。OBJECTIVE To provide reference for selecting drug treatment plans in clinical practice,the economic benefits of domestic and imported human erythropoietin in the treatment of elderly patients with anemia were compared.METHODS 38 cases in each group of elderly patients with anemia who were treated with domestic and imported human erythropoietin injections in a hospital from January 2019 to May 2024 were retrospectively reviewed.Minimum cost analysis of the two schemes in the treatment of anemia patients was conducted using the data after matching propensity scores.RESULTS The number of cases in the 2 groups was 37 and 33 after matching,respectively.Showing no significant differences in gender,age,pre-medication hemoglobin levels,or disease type between the two groups after matching.The total effective rate was calculated with HGB rising≥10 g·L^(-1),and the effective rate was 51.51%and 48.65%(P>0.05),respectively.The total cost of domestic and imported human erythropoietin in treating anemia was(389.29±77.62)yuan and(1884.29±554.05)yuan,respectively(P<0.01).The linear regression results showed that the model was well constructed,and there was no significant influence on the effect of each factor.CONCLUSION Compared with imported human erythropoietin,domestic human erythropoietin had no statistical significance in the clinical efficacy and safety for elderly patients hospitalized with anemia for about one month.However,it offered better benefits in short-term economic.

关 键 词：人促红素 国产 进口 成本-效果分析 倾向性评分匹配 

分 类 号：R956[医药卫生—药学]