某院2016~2023年乳腺脓肿的病原菌分布及耐药性分析  

Pathogen Distribution and Antibiotic Resistance of Breast Abscess in a Certain Hospital from 2016 to 2023

作　　者：闫小利 林玉玲 陈清清[1] 宋瑞雅 张建明 YAN Xiao-li;LIN Yu-ling;CHEN Qing-qing;SONG Rui-ya;ZHANG Jian-ming(Department of Laboratory Medicine,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 36200,China)

机构地区：[1]福建医科大学附属泉州第一医院,福建泉州362000

出　　处：《海峡药学》2024年第10期72-75,共4页Strait Pharmaceutical Journal

基　　金：泉州市科技局计划项目(2023NS046)。

摘　　要：目的了解我院乳腺脓肿的病原菌分布及耐药性,为临床合理应用抗菌药物提供参考。方法回顾性分析我院2016年1月~2023年11月乳腺脓肿脓液培养阳性标本病原菌种类,统计常见致病菌的药敏特点。结果乳腺脓肿患者共192例,其中哺乳期患者89例,非哺乳期患者103例。共分离到192株细菌,革兰阳性菌185株,包括108株金黄色葡萄球菌,31株凝固酶阴性葡萄球菌,30株棒状杆菌属细菌,15株链球菌属细菌,1株粪肠球菌;革兰阴性菌7株,其中肠杆菌目细菌5株。金黄色葡萄球菌及凝固酶阴性葡萄球菌对苯唑西林的耐药率分别为37.0%、58.1%,对万古霉素、替考拉宁、利奈唑胺的敏感率均为100%。结论我院非哺乳期乳腺脓肿患者较多,分离的病原菌以金黄色葡萄球菌为主,耐甲氧西林金黄色葡萄球菌(MRSA)和凝固酶阴性葡萄球菌(MRCN)分离率高,应及时进行病原菌培养及药敏试验,制订合理的抗感染治疗方案。OBJECTIVE To study pathogen distribution,and drug resistance of breast abscess in our hospital in order to provide a reference for using antibiotics reasonably.METHODS A retrospective analysis was conducted on the types of pathogenic bacteria of breast abscess pus culture positive specimens in our hospital from January 2016 to November 2023,and the drug sensitivity characteristics of common pathogens were analyzed.RESULTS There were a total of 192 patients with breast abscess,including 89 lactating patients and 103 non-lactating patients.192 strains of pathogens were isolated from pus samples,including 185 strains of gram positive bacteria which consisted of 108 strains of Staphylococcus aureus,31 strains of coagulase negative Staphylococcus,30 strains of Corynebacterium,15 strains of Streptococcus,and 1 strain of Enterococcus faecalis;7 strains of gram-negative bacteria,which included 5 strains of Enterobacteriaceae.The resistance rates of Staphylococcus aureus and coagulase negative Staphylococcus to oxacillin were 37.0%and 58.1%,respectively.The sensitivity rates to vancomycin,teicoplanin,and linezolid were all 100%.CONCLUSION There are more non-lactating patients with breast abscess in our hospital,and the predominant pathogens were Staphylococcus aureus.The isolation rates of MRSA and MRCN were high,and pathogen culture and antimicrobial susceptibility testing should be carried out as soon as possible,to develop a reasonable anti-infection treatment plan.

关 键 词：乳腺脓肿 病原菌 哺乳期 非哺乳期 抗菌药物 

分 类 号：R969[医药卫生—药理学]