ncRNA介导的肝细胞癌脂肪酸代谢重编程研究进展  

Advances in ncRNA-mediated reprogramming of fatty acid metabolism in hepatocellular carcinoma

作　　者：张凯楠 张林敏(综述) 伏建峰(审校)[2] ZHANG Kainan;ZHANG Linmin;FU Jianfeng(Graduate School of Xinjiang Medical University,Urumqi,Xinjiang 830017,China;Clinical Laboratory Diagnostic Center,Xinjiang Military Command General Hospital,Urumqi,Xinjiang 830017,China)

机构地区：[1]新疆医科大学研究生学院,新疆乌鲁木齐830017 [2]新疆军区总医院全军临床检验诊断中心,新疆乌鲁木齐830017

出　　处：《检验医学与临床》2024年第21期3251-3255,共5页Laboratory Medicine and Clinic

基　　金：新疆维吾尔自治区自然科学基金面上项目(2022D01C245)。

摘　　要：肝细胞癌(HCC)侵袭性强、预后不佳,其防治一直是临床医学关注的焦点和亟待解决的难题。脂肪酸代谢的异常与HCC的发生、发展存在密切联系,从HCC脂肪酸代谢的过程和特点着手,有可能是解决HCC防治难题的关键。研究显示,非编码RNA(ncRNA)介导的HCC脂肪酸代谢重编程是影响HCC发生、发展的重要机制。该文总结了近年来ncRNA介导HCC脂肪酸代谢重编程的研究进展,包括脂肪酸代谢在HCC进程中的效应作用、ncRNA调节HCC的脂肪酸代谢重编程和针对HCC中靶向脂肪酸代谢的ncRNA的治疗潜力。通过层级论述、分析,阐明ncRNA调控HCC脂肪酸代谢重编程、进而制约影响HCC演进进程的作用。基于对ncRNA介导HCC脂肪酸代谢重编程的新认知,ncRNA有望为临床HCC防治探寻药物作用新靶点和研发药物前体,提供新思路和新途径,并为可能的新药目标化合物设计和深入的药物构效关系研究提供借鉴和参考。Hepatocellular carcinoma(HCC)is highly invasive with a poor prognosis,making its prevention and treatment a central focus in clinical medicine and an urgent challenge to address.Abnormal fatty acid metabolism is closely linked to the occurrence and progression of HCC.Investigating the processes and characteristics of fatty acid metabolism in HCC may provide critical insights into overcoming these challenges.Recent studies have demonstrated that non-coding RNA(ncRNA)-mediated reprogramming of fatty acid metabolism is a key mechanism influencing the development and progression of HCC.This review summarizes the recent research advances on ncRNA-mediated reprogramming of fatty acid metabolism in HCC,including the role of fatty acid metabolism in HCC progression,ncRNA regulation of metabolic reprogramming,and the therapeutic potential of ncRNAs targeting fatty acid metabolism in HCC.Through a detailed discussion and analysis,the regulatory role of ncRNAs in reprogramming fatty acid metabolism,and their impact on constraining HCC evolution,are elucidated.Based on this emerging understanding,ncRNAs hold promise for identifying new therapeutic targets,developing drug precursors for HCC prevention and treatment,and guiding the design of novel compounds for future drugs.These insights may also inform deeper studies of drug structure-activity relationships.

关 键 词：肝细胞癌 脂肪酸代谢 长链非编码RNA 代谢重编程 非酒精性脂肪肝 

分 类 号：R446.1[医药卫生—诊断学] R735.7[医药卫生—临床医学]