乌司他丁治疗急性胰腺炎的快速卫生技术评估  

Rapid health technology assessment of ulinastatin in the treatment of acute pancreatitis

作　　者：郑子恢[1] 赵紫楠[1] 高峰 李文英[1] 原涵[1] 张白歌 杨莉萍[1] 金鹏飞[1] ZHENG Zihui;ZHAO Zinan;GAO Feng;LI Wenying;YUAN Han;ZHANG Baige;YANG Liping;JIN Pengfei(Dept.of Pharmacy,Beijing Hospital/National Geriatric Center/Institute of Geriatrics,Chinese Academy of Medical Sciences/Beijing Key Laboratory of Clinical Risk and Individualized Application Evaluation of Drugs(Beijing Hospital),Beijing 100730,China;Health Care Department,Security Bureau of Joint Staff Department of the Central Military Commission,Beijing 100173,China)

机构地区：[1]北京医院药学部/国家老年医学中心/中国医学科学院老年医学研究院/北京市药物临床风险与个体化应用评价重点实验室(北京医院),北京100730 [2]中央军委联合参谋部警卫局卫生保健处,北京100173

出　　处：《中国药房》2024年第21期2676-2683,共8页China Pharmacy

基　　金：国家卫生健康委创新药物上市后临床研究科研专项(No.WKZX2023CX210007)。

摘　　要：目的本文通过对乌司他丁(UTI)进行快速卫生技术评估(HTA),评价UTI治疗急性胰腺炎(AP)的有效性、安全性及经济性。方法计算机检索PubMed、Embase、the Cochrane Library、中国知网、万方数据库、中国生物医学文献数据库和HTA机构官方网站,收集UTI在AP方面的系统评价(SR)/Meta分析、经济学评价及HTA报告,检索时限为建库至2024年4月。由2名研究者根据纳排标准独立进行筛选、质量评价和数据提取,采取描述性分析方式对数据进行分析汇总。结果共纳入19篇研究,包括15篇SR/Meta分析和4篇经济学研究,未检索到HTA报告。UTI联合治疗AP较单独常规治疗在提高总有效率、缩短淀粉酶恢复时间、减少腹痛腹胀缓解时间、降低病死率及缩短平均住院天数等方面均具有明显优势,和其他阳性药物(甲磺酸加贝酯、奥曲肽、生长抑素)相比疗效相当或基本一致,安全性良好。就目前纳入的研究而言,UTI对比其他阳性药物具有明显经济学优势。结论UTI在治疗AP方面安全有效,具有经济学优势。OBJECTIVE To conduct rapid health technology assessment(HTA)of ulinastatin(UTI),and to evaluate the efficacy,safety and cost-effectiveness of UTI in the treatment of acute pancreatitis(AP).METHODS Retrieved from PubMed,Embase,the Cochrane Library,CNKI,Wanfang database,CBM and official websites of HTA institutions,the systematic review(SR)/meta-analysis,economic evaluation and HTA reports of UTI in the treatment of AP were collected from the inception to Apr.2024.Two researchers independently conducted screening,quality evaluation and data extraction according to the admission and exclusion criteria,and descriptive analysis was adopted to analyze and summarize the data.RESULTS A total of 19 studies were included,involving 15 SR/meta-analysis and 4 economic studies,and no HTA report was retrieved.In the treatment of AP,UTI showed clear advantages over conventional treatment alone in terms of improving the overall effective rate,shortening the recovery time of amylase,reducing the time required to relieve abdominal pain and distension,lowering the mortality rate,and decreasing the average hospital stay.Compared to other positive drugs(carbendate mesylate,octreotide,somatostatin,etc.),its efficacy is similar,with a favorable safety profile.As far as the current research was concerned,UTI had obvious economic advantages over other positive drugs.CONCLUSIONS UTI is safe and effective in the treatment of AP,and has economic advantages.

关 键 词：乌司他丁 急性胰腺炎 有效性 安全性 经济性 快速卫生技术评估 循证学评价 

分 类 号：R969[医药卫生—药理学] R956[医药卫生—药学]