黄体酮增溶制剂技术研究进展  

Research advances in solubility-enhancing formulation technologies for progesterone

作　　者：江婷婷 汪云云 武香香[2] 曾华辉[2] 朱鑫[1] JIANG Tingting;Wang Yunyun;Wu Xiangxiang;ZENG Huahui;Zhu Xin(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450018,China;Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450018,China)

机构地区：[1]河南中医药大学药学院,郑州450018 [2]河南中医药大学中医药科学院,郑州450018

出　　处：《中国药房》2024年第21期2703-2708,共6页China Pharmacy

基　　金：河南省科技发展计划项目(No.242102310525);河南省科技研发计划联合基金(优势学科培育类)项目(No.222301420060)。

摘　　要：黄体酮是目前临床上治疗、预防先兆流产和习惯性流产的一线药物,但由于具有特殊的化学结构,导致其溶解度低,限制了其在临床的应用。因此,黄体酮增溶制剂新技术和新剂型是其研究开发的重要方向。本文对近年来黄体酮增溶制剂技术的研究进展进行了综述,发现可通过固体分散体技术、包合技术、微粉化、纳米化(包括纳米混悬剂、聚合物胶束、纳米粒等)、脂质体技术、自乳化、共晶技术、3D打印这8项技术来增大黄体酮的溶解度,提高其生物利用度,减少其毒副作用,从而更好地服务于临床。Progesterone is currently the first-line drug for clinical treatment and prevention of threatened abortion and habitual abortion.However,due to its special chemical structure,its solubility is low,which limits its clinical application.Therefore,the new technology and new dosage form of progesterone solubilization preparation is an important direction of its research and development.In this paper,the research progress of progesterone solubilization preparation technology in recent years is reviewed.It is found that the water solubility of progesterone can be enhanced by solid dispersion technology,inclusion technology,micronization,nanocrystallization(including nanosuspensions,polymer micelles,nanoparticles,etc.),liposome technology,selfemulsification,cocrystal technology,and 3D printing.Eight technologies are used to increase the solubility of progesterone,improve its bioavailability and reduce its toxic and side effects,to serve the clinic better.

关 键 词：黄体酮 制剂技术 溶解度 生物利用度 增溶技术 

分 类 号：R943[医药卫生—药剂学]