成年男性腰椎骨密度与代谢综合征的相关性  

Correlations of lumbar bone mineral density and metabolic syndrome in adult males

作　　者：林新贝 孙永兵 邹智 武肖玲 李中林 王玲 朱嘉栋 李永丽 李昊 LIN Xinbei;SUN Yongbing;ZOU Zhi;WU Xiaoling;LI Zhonglin;WANG Ling;ZHU Jiadong;LI Yongli;LI Hao(Department of Medical Imaging,Henan Key Laboratory of Chronic Disease Health Management,People's Hospital of Zhengzhou University/Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Nuclear Medicine,Henan Key Laboratory of Chronic Disease Health Management,People's Hospital of Zhengzhou University/Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Health Management,Henan Key Laboratory of Chronic Disease Health Management,People's Hospital of Zhengzhou University/Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Health Management,Fuwai Central China Cardiovascular Hospital,Zhengzhou 451460,China)

机构地区：[1]郑州大学人民医院/河南省人民医院医学影像科,河南郑州450003 [2]郑州大学人民医院/河南省人民医院核医学科,河南郑州450003 [3]郑州大学人民医院/河南省人民医院健康管理学科、河南省慢病健康管理重点实验室,河南郑州450003 [4]阜外华中心血管病医院健康管理学科,河南郑州451460

出　　处：《中国医学影像技术》2024年第10期1562-1566,共5页Chinese Journal of Medical Imaging Technology

基　　金：河南省科技发展计划项目(242102311121)。

摘　　要：目的观察成年男性腰椎骨密度(BMD)与代谢综合征(MS)的相关性。方法回顾性分析13490名成年男性低剂量胸部CT联合定量CT,测量其腰椎BMD,判断有无MS及其程度,分析成年男性腰椎BMD值与有无MS或MS程度的相关性,以及腰椎BMD值与MS相关因素的关系。以腰椎BMD值为因变量,将年龄、低密度脂蛋白胆固醇(LDL-C)、血尿酸(BUA)、血红蛋白(Hb)及有无MS纳入多元线性回归分析,观察其对腰椎BMD值的影响。结果13490名成年男性中,MS 3900例(MS组)、非MS 9590名(非MS组),组间BMD差异有统计学意义(P=0.001)。腰椎BMD值与有无MS(r_(s)=-0.025,P=0.004)及MS程度(r_(s)=-0.038,P<0.001)均呈负相关,与腹型肥胖、高甘油三酯及低HDL-C均呈正相关(r_(s)=0.024、0.061、0.036,P均<0.001),与高血压及高血糖均呈负相关(r_(s)=-0.135、-0.104,P均<0.05)。矫正年龄因素后,成年男性腰椎BMD值与有无MS及LDL-C均呈负相关(P均<0.05),与BUA及Hb均呈正相关(P均<0.001)。结论成年男性腰椎BMD值与MS相关。Objective To explore the correlations of lumbar bone mineral density(BMD)and metabolic syndrome(MS)in adult males.Methods Data of low dose chest CT and quantitative CT of 13490 adult males were retrospectively analyzed,and lumbar BMD were measured to judge whether MS existed and the degree of MS,and the correlations of lumbar BMD with MS or not and the degree of MS,as well as of lumbar BMD value and the related indicators of MS were assessed.Taken lumbar BMD as the dependent variable,the age,low density lipoprotein cholesterol(LDL-C),blood uric acid(BUA),hemoglobin(Hb)and MS or not were included in multiple linear regression analysis to observe the impact of MS and related indicators on lumbar BMD.Results Among 13490 adult males,3900 were found with MS(MS group),while 9590 were found without MS(non-MS group).Significant difference of lumbar BMD was detected between groups(P=0.001).Lumbar BMD values were negatively correlated with MS(r_(s)=-0.025,P=0.004)and the degree of MS(r_(s)=-0.038,P<0.001),whereas positively correlated with abdominal obesity,high triglyceride and low HDL-C or not(r_(s)=0.024,0.061,0.036,all P<0.001)but negatively correlated with hypertension and hyperglycemia or not(r_(s)=-0.135,-0.104,both P<0.05).After adjustment of age,lumbar BMD of adult males was negatively correlated with MS or not as well as LDL-C(both P<0.05),but positively correlated with BUA and Hb(both P<0.001).Conclusion Lumbar BMD was associated with MS in adult males.

关 键 词：骨密度 代谢综合征 体层摄影术 X线计算机 男性 

分 类 号：R714.257[医药卫生—妇产科学] R814.42[医药卫生—临床医学]