老年期与儿童期特应性皮炎的临床特征及实验室检查指标差异性分析  

Analysis on differences in clinical characteristics and laboratory test indicators between elderly and childhood atopic dermatitis patients

作　　者：陈沛然 刘文韬 Angela Wu 周昕 韩乐[1] 黎雅婷[2,3] 陆春[1] 冯佩英[2] CHEN Peiran;LIU Wentao;Angela WU;ZHOU Xin;HAN Le;LI Yating;LU Chun;FENG Peiying(Dermatology and Aesthetic Plastic Department,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Allergy,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Pediatrics,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院皮肤与整形美容科,广州510630 [2]中山大学附属第三医院变态反应(过敏)科,广州510630 [3]中山大学附属第三医院儿科,广州510630

出　　处：《中华临床免疫和变态反应杂志》2024年第5期446-451,共6页Chinese Journal of Allergy & Clinical Immunology

基　　金：广东省自然科学基金(2020A1515011183)。

摘　　要：目的分析特应性皮炎儿童期及老年期在临床特征及实验室检查指标的异同。方法收集2020年9月至2023年3月在中山大学附属第三医院皮肤与整形美容科及变态反应科就诊的儿童期及老年期特应性皮炎患的临床资料及实验室检查,分析两组临床特征与实验室检查指标的差异。定量资料组间比较采用t检验或单因素方差(ANOVA)分析。结果共纳入98例儿童期特应性皮炎患者及46例老年特应性皮炎患者。老年期患者男性明显多于女性(P<0.05),且皮疹更容易泛发全身,且多累及躯干及下肢,且以伸侧部位为主(P<0.05)。儿童期较老年期更多见合并过敏性鼻炎、哮喘等特应性疾病(P<0.05);过敏原特异性IgE阳性率明显高于老年期患者(P<0.05)。结论儿童期与老年期特应性皮炎患者在性别分布、合并特应性疾病、皮损特征及分布和过敏原特异性IgE阳性率等方面存在统计学差异,临床需正确认识两者的异质性。Objective To analyze similarities and differences in clinical features and laboratory test indicators between children and elderly patients with atopic dermatitis.Methods Clinical data and laboratory tests of pediatric and elderly patients with atopic dermatitis were collected,who visited Department of Dermatology and Aesthetic Plastic and Department of Allergy,the Third Affiliated Hospital of Sun Yat-sen University since September 2020 to March 2023.The differences in clinical features and laboratory test indicators between two age groups were analyzed.Quantitative data were compared by using t test or one-way analysis of variance(ANOVA).Results A total of 98 children with atopic dermatitis and 46 elderly patients with atopic dermatitis were included in this study.There were more males than females in elderly group(P<0.05).In addition,generalized rashes was more frequent among elderly patients with majority on trunk,lower limbs as well as extension sides(P<0.05).Atopic diseases such as allergic rhinitis and asthma were more common among children compared with elderly(P<0.05).The positive rate of allergen specific IgE was significantly higher in children than that of elderly patients(P<0.05).Conclusion There are statistically significant differences in gender,comorbid atopic diseases,cutaneous lesion characteristics and distribution,positive rates of allergen specific IgE between children and elderly patients with atopic dermatitis.Clinicians need to correctly understand the heterogeneity between two age groups.

关 键 词：特应性皮炎 儿童 老年 临床特征 实验室检查指标 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]