IgG4相关消化系统疾病的研究进展  

Research progress on IgG4-related digestive diseases

作　　者：李妮 刘展[1] Li Ni;Liu Zhan(Department of Gastroenterology,Hunan Provincial People's Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha 410005,China)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)消化内科,长沙410005

出　　处：《中国医师杂志》2024年第10期1583-1588,共6页Journal of Chinese Physician

基　　金：湖南省卫生健康委科研计划(202103030035)。

摘　　要：IgG4相关性疾病(IgG4-RD)是一类自身免疫功能紊乱引起, 以慢性纤维化炎症为特征的多系统性疾病。IgG4-RD是一种被低估的罕见病, 特别是IgG4相关消化系统疾病(IgG4 DSD)的发病情况研究较少, 目前国内没有针对IgG4相关消化系统疾病的专家共识或指南。该疾病常被误诊为肿瘤、炎症和感染性疾病, 可能导致终末期器官衰竭, 预后差。本文将从IgG4相关消化系统疾病的流行病学、诊断标准、IgG4相关消化系统疾病与肿瘤的关系、IgG4相关消化系统疾病和糖尿病关系、治疗等几个方面来阐述, 以期提高临床医生对该病的认识, 完善该病的诊疗路径。IgG4-related diseases(IgG4-RD)are multi-systemic conditions resulting from autoimmune disorders and characterized by chronic fibrotic inflammation.Among these,IgG4 digestive system disorders(IgG4-DSD)remain an underrecognized rare disease in China,lacking expert consensus or established guidelines.The condition is frequently misdiagnosed as neoplastic,inflammatory,or infectious processes and can lead to end-stage organ failure with a poor prognosis.This article aims to discuss the epidemiology of IgG4 digestive system diseases,diagnostic criteria,the association between these diseases and tumors as well as diabetes mellitus,treatment options,and other relevant aspects to enhance clinicians'understanding and improve diagnostic and therapeutic pathways for this condition.

关 键 词：免疫球蛋白G4相关疾病 消化系统疾病 

分 类 号：R593[医药卫生—内科学]