嗜酸性粒细胞在COPD中的临床及免疫机制研究进展  

Research progress on clinical and immune mechanism of eosinophils in COPD

作　　者：宋春雪 王亮亮 刘柳 魏霞 Song Chunxue;Wang Liangliang;Liu Liu;Wei Xia(Department of Clinical Medicine,Medical School of Yan'an University,Yan'an 716000,China;Department of Pulmonary and Critical Care Medicine,the Ninth Hospital of Xi'an,Xi'an 710054,China;Graduate School of Xi'an Medical University,Xi'an 710021,China)

机构地区：[1]延安大学医学院临床医学系,延安716000 [2]西安市第九医院呼吸与危重症医学科,西安710054 [3]西安医学院研究生院,西安710021

出　　处：《中国医师杂志》2024年第10期1588-1593,共6页Journal of Chinese Physician

基　　金：西安市卫生健康委员会青年培育项目(2023qn10);西安市科技计划项目(21YXYJ0070)。

摘　　要：慢性阻塞性肺疾病(COPD)是一种复杂的以气道炎症为特征的异质性疾病,其中以嗜酸性粒细胞(EOS)为主的气道炎症在COPD的发生发展中日益受到关注,EOS型COPD是庞大的COPD患者中的一个特殊人群。近年来,有关EOS型COPD有较多的研究,涉及2型免疫反应,COPD病情进展以及糖皮质激素的应用等方面,笔者就上述关系作一综述。有利于进一步了解EOS型COPD,为COPD的临床诊疗提供帮助。Chronic obstructive pulmonary disease(COPD)is a complex and heterogeneous disease characterized by airway inflammation.Airway inflammation dominated by eosinophils(EOS)has attracted increasing attention in the occurrence and development of COPD.EOS type COPD is a special population in a large number of COPD patients.In recent years,there have been many studies on EOS type COPD,involving type 2 immune response,COPD progression and the use of glucocorticoids.This article reviews the above relationships.It is helpful to further understand EOS type COPD and provide help for the clinical diagnosis and treatment of COPD.

关 键 词：肺疾病 慢性阻塞性 嗜酸性粒细胞 糖皮质激素 

分 类 号：R563.9[医药卫生—呼吸系统]