玻璃体腔注射阿柏西普对糖尿病视网膜病变患者血管内皮生长因子水平及视觉功能的影响  

Effect of intravitreal injection of Arbocept on vascular growth factor level and visual function in diabetic retinopathy

作　　者：彭梅 林浓浓 张艳芳 曾晓瑜 PENG Mei;LIN Nongnong;ZHANG Yanfang;ZENG Xiaoyu(Department of Ophthalmology,Yichun People's Hospital,Jiangxi Province,Yichun 336000,China;Department of Ophthalmology,Yichun Hospital of Traditional Chinese Medicine,Jiangxi Province,Yichun 336000,China)

机构地区：[1]江西省宜春市人民医院眼科,江西宜春336000 [2]江西省宜春市中医院眼科,江西宜春336000

出　　处：《中国当代医药》2024年第30期65-68,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2021B347)。

摘　　要：目的 探讨玻璃体腔注射阿柏西普治疗糖尿病视网膜病变(DR)的效果。方法 选取2021年1月至2023年10月宜春市人民医院收治的100例DR患者作为研究对象,按照随机数字表法分为观察组(50例)和对照组(50例),观察组采用阿柏西普治疗,对照组采用曲安奈德治疗,均治疗3个月。比较两组治疗效果、视觉功能及血管内皮生长因子(VEGF)水平。结果 观察组[96.00%(48/50)]的总有效率高于对照组[78.00%(39/50)],差异有统计学意义(P<0.05);治疗后,两组最佳矫正视力(BCVA),30°视敏度、60°视敏度均高于治疗前,观察组BCVA,30°灵敏度、60°视敏度高于对照组,差异有统计学意义(P<0.05);治疗后,两组VEGF-A、VEGF-B水平均低于治疗前;观察组VEGF-A、VEGF-B水平低于对照组,差异有统计学意义(P<0.05)。结论 DR患者采用玻璃体腔注射阿柏西普治疗效果较为满意,可有效改善视觉功能,调节VEGF水平。Objective To investigate the effect of intravitreal injection of Arbocept in the treatment of diabetic retinopathy(DR).Methods A total of 100 DR patients admitted to the of Yichun People's Hospital from January 2021 to October 2023 were selected as the study subjects and they were randomly divided into observation group(50 cases)and control group(50 cases)according to the random number table method.The observation group was treated with Abiercept,and the control group was treated with Triamcinolide,all of which were treated for 3 months.Treatment effect,visual function,and vascular endothelial growth factor(VEGF)level were compared between the two groups.Results The total effective rate of observation group was 96.00%(48/50)higher than that of control group 78.00%(39/50),the difference was statistically significant(P<0.05).After treatment,the best corrected visual acuity(BCVA),visual acuity of 30°and 60°were higher than before treat-ment in both groups,and the BCVA,visual acuity of 30°and 60°in observation group were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,VEGF-A and VEGF-B levels in both groups were lower than before treatment,and the levels of VEGF-A and VEGF-B in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).Conclusion The effect of intravitreal injection of Arbocept in DR patients is satisfactory,which can effectively improve visual function and regulate VEGF level.

关 键 词：糖尿病视网膜病变 视觉功能 阿柏西普 血管内皮生长因子 

分 类 号：R587.1[医药卫生—内分泌]