胰岛素泵长期持续皮下胰岛素输注治疗儿童1型糖尿病效果的影响因素  

Influencing factors of the effect of long-term continuous subcutaneous insulin infusion with insulin pump in the treatment of type 1 diabetes mellitus in children

作　　者：刘燕凤 陈婷丽 郑忠实 LIU Yanfeng;CHEN Tingli;ZHENG Zhongshi(Department of Paediatric Endocrinology,Quanzhou Women's and Children's Hospital,Fujian Province,Quanzhou 362000,China)

机构地区：[1]福建省泉州市妇幼保健院·儿童医院儿童内分泌科,福建泉州362000

出　　处：《中国当代医药》2024年第29期75-78,共4页China Modern Medicine

摘　　要：目的探究胰岛素泵长期持续皮下胰岛素输注(CSII)治疗儿童1型糖尿病(T1DM)效果的影响因素。方法选取2021年1月至2022年12月在泉州市妇幼保健院·儿童医院接受CSII治疗的130例T1DM患儿作为研究对象,依据病历系统记录6个月后的空腹血糖(FPG)、餐后2 h血糖(2 h PBG)及糖化血红蛋白(HbA1c)达标情况分为对照组(达标组,100例)、观察组(未达标组,30例),收集比较患儿相关资料,使用多因素logistic回归分析,分析胰岛素泵长期CSII治疗儿童T1DM效果的影响因素。结果两组患儿父母文化程度、家庭月收入、服药情况、胰岛素β细胞分泌指数(Homa-β)、胰岛素抵抗指数(Homa-IR)比较,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,父母文化程度(β=1.159,OR=3.188,95%CI:1.372~7.403)、家庭月收入(β=1.286,OR=3.619,95%CI:1.544~8.480)、服药情况(β=1.168,OR=1.632,95%CI:1.017~3.711)为CISS对T1DM患儿治疗效果的危险因素(OR>1,P<0.05),Homa-β(β=-2.383,OR=0.092,95%CI:0.015~0.552)、Homa-IR(β=-3.402,OR=0.033,95%CI:0.003~0.387)为CSII对T1DM患儿治疗效果的保护因素(OR<1,P<0.05)。结论T1DM患儿长期CSII疗效的影响因素包含父母文化程度、家庭月收入、服药情况、Homa-β、Homa-IR,临床应对以上因素保持关注。Objective To explore the influencing factors of the effect of long-term continuous subcutaneous insulin infusion(CSII)with insulin pump in the treatment of type 1 diabetes mellitus(T1DM)in children.Methods A total of 130 children with T1DM who received treatment in Quanzhou Women's Children's Hospital from January 2021 to December 2022 were selected as the study objects.The fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 h PBG)and glycated hemoglobin(HbA1c)reached the standard 6 months later recorded in the medical record system were divided into control group(100 cases)and observation group(30 cases).The relevant data of the children were collected and compared,and the logistic regression was applied to analyze the influencing factors of the efficacy of long-term CSII with insulin pump in the treatment of T1DM in children.Results There were statistically significant differences in parental education,monthly household income,medication status,homeostasis model assessment-β(Homa-β)and homeostasis model assessment-insulin resistance(Homa-IR)between the two groups(P<0.05).Logistic regression analysis results indicated that parental education level(β=1.159,OR=3.188,95%CI:1.372-7.403),monthly family income(β=1.286,OR=3.619,95%CI:1.544-8.480),medication status(β=1.168,OR=1.632,95%CI:1.017-3.711)were the risk factors for treatment effect in children with T1DM(OR>1,P<0.05),Homa-β(β=-2.383,OR=0.092,95%CI:0.015-0.552),Homa-IR(β=-3.402,OR=0.033,95%CI:0.003-0.387)were protective factors for treatment effect in children with T1DM(OR<1,P<0.05).Conclusion The influencing factors of the long-term efficacy of T1DM children include parental education level,family monthly income,medication status,Homa-βand Homa-IR.Attention should be maintained to the above factors in clinical practice.

关 键 词：1型糖尿病 胰岛素泵 持续皮下胰岛素输注 影响因素 

分 类 号：R587.1[医药卫生—内分泌]