苯磺酸氨氯地平及沙库巴曲缬沙坦对高血压患者的疗效及对心肾功能、血脂指标的影响  

Efficacy of amlodipine besylate and sacubitril valsartan on cardiac and renal function and blood lipid indexes in hypertensive patients

作　　者：邹婷 温春生 祖努然·拜克里 唐瑞 ZOU Ting;WEN Chunsheng;Zunuran Baikeli(Department of Hypertension,the Fifth Affiliated Hospital of Xinjiang Medical University,Xinjiang,Urumqi 830000,China;不详)

机构地区：[1]新疆医科大学第五附属医院高血压科,乌鲁木齐市830000 [2]新疆医科大学第五附属医院呼吸科,乌鲁木齐市830000

出　　处：《河北医药》2024年第21期3284-3287,共4页Hebei Medical Journal

基　　金：新疆医科大学第五附属医院院级科研项目(编号:XYDWFY-ZR-202301)。

摘　　要：目的研究苯磺酸氨氯地平(AB)及沙库巴曲缬沙坦(SV)对高血压患者的疗效及对心肾功能及血脂指标的影响。方法选取2021年3月至2022年4月收治的高血压患者80例,随机数字表法分为观察组和对照组,每组40例。对照组给予AB治疗,观察组在对照组的基础上增加口服SV治疗。比较2组的治疗效果和治疗前后心功能的指标[左心室内径(LV)、左心房内径(LA)、室间隔厚度(IVS)、射血分数(EF)]、肾功能指标[尿酸(UA)、肌酐(Scr)、同型半胱氨酸(Hcy)、肾小球滤过率(eGFR)]、血脂指标[三酰甘油(TG)、低密度脂蛋白(LDL-C)、胆固醇(TC)]。结果观察组治疗总有效率为92.50%明显高于对照组的75.00%(P<0.05)。2组治疗前LA、LV、IVS、EF水平差异无统计学意义(P>0.05),治疗后2组LA、LV以及IVS水平均降低,但观察组下降程度明显大于对照组(P<0.05)。治疗后2组EF水平均提高,观察组提高更显著(P<0.05)。2组治疗前UA、Scr、Hcy、eGFR水平差异无统计学意义(P>0.05),治疗后2组UA以及Scr水平均明显降低,且观察组下降程度明显大于对照组(P<0.05);治疗后2组Hcy以及eGFR水平均提升,观察组提高更显著(P<0.05)。2组治疗前TG、LDL-C、TC水平差异无统计学意义(P>0.05),治疗后2组TG、LDL-C、TC水平均降低,观察组下降程度明显大于对照组(P<0.05)。结论在高血压的治疗中,给予患者AB和SV联用的治疗效果更好,同时还能改善患者的心、肾功能以及血脂指标,值得推广。Objective To study the effect of amlodipine besylate(AB)and sacubitril valsartan(SV)on cardiac and renal function and blood lipid indexes in hypertensive patients.Methods Eighty hypertensive patients admitted to our hospital from March 2021 to April 2022 were selected and divided into observation group(n=40)and control group(n=40)by a random number table.All patients were treated with AB,those in the observation group added SV.The treatment effect and indicators of cardiac function including left ventricular(LV)diameter,left atrial(LA)diameter,interventricular septum(IVS)thickness,ejection fraction(EF),renal function index including uric acid(UA),creatinine(Scr),homocysteine(Hcy),estimated glomerular filtration rate(eGFR),and lipid index including triglyceride(TG),low density lipoprotein cholesterol(LDL-C),total cholesterol(TC)were compared between the two groups.Results The total response rate in the observation group was significantly higher than that in the control group(92.50%vs 75.00%,P<0.05).There was no significant difference in the levels of LA,LV,IVS and EF before treatment between the two groups(P>0.05).After treatment,the levels of LA diameter,LV diameter and IVS thickness in the two groups decreased significantly,and the decrease in the observation group was significantly greater than that in the control group(P<0.05).The level of EF in the two groups increased significantly,and the increase was more pronounced in the observation group(P<0.05).There was little difference in UA,Scr,Hcy,and eGFR levels between the two groups(P>0.05).But with significantly lower levels of UA and Scr,and higher Hcy and eGFR in both groups after treatment(P<0.05),and the improvement was more significant in the observation group relative to the control group(P<0.05).The TG,LDL-C,and TC levels were little different between the two groups before treatment(P>0.05).TG,LDL-C and TC levels decreased significantly in both groups after treatment,the decrease in the observation group was greater than control group(P<0.05).Conclusion

关 键 词：苯磺酸氨氯地平 沙库巴曲缬沙坦 高血压 治疗结果 心肾功能 血脂指标 

分 类 号：R544.1[医药卫生—心血管疾病]