内皮系统基因及多态性与高血压的相关性研究进展  

Research progress on correlation of endothelial system genes and their polymorphisms with hypertension

作　　者：常丽 纪仁晖 安彩艳 CHANG Li;JI Renhui;AN Caiyan(Basic Medical College,Inner Mongolia Medical University,Inner Mongolia,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学基础医学院,呼和浩特市010050 [2]内蒙古自治区呼和浩特市第一医院基础与转化医学研究中心

出　　处：《河北医药》2024年第21期3310-3315,共6页Hebei Medical Journal

基　　金：国家自然科学基金地区基金项目(编号:31960149);内蒙古医科大学致远计划项目-蒙古族心脑血管疾病和肿瘤遗传学治学人才团队项目(编号:ZY0120024);呼和浩特市卫生健康委员会医疗卫生科技计划项目(编号:呼卫健医疗-2023023);呼和浩特市第一医院博士科研启动基金项目[编号:2023SYY(BS)001]。

摘　　要：高血压是常见的慢性病,是以动脉血压持续升高为特征的心血管综合征,是我国心脑血管病死亡的重要原因。目前高血压已成为一个严峻的公共卫生问题。高血压发病机制复杂多样,随着对发病机制的不断探索,发现遗传因素在高血压的发生发展中起着重要作用。其中内皮系统基因及其动态性在高血压中发挥的作用已逐渐成为研究热点。现就几个内皮系统基因及其多态性与高血压的关系展开论述,以期为临床高血压的诊断和治疗提供新的思路。Hypertension is a common chronic disease,serving as a cardiovascular syndrome characterized by persistent elevation of arterial blood pressure.It is an important cause of cardiovascular and cerebrovascular deaths in China.Hypertension has now become a serious public health problem.The pathogenesis of hypertension is complex and varied.With the deep mining of the pathogenesis,genetic factors have been unveiled for their important roles in the development of hypertension.Among them,endothelial system genes and their polymorphisms have been well concerned as a hot research topic.This review explored the correlation of the endothelial system genes and their polymorphisms with hypertension,thus providing new insights into the diagnosis and treatment of hypertension.

关 键 词：高血压 内皮型-氧化氮合酶 内皮素-1 E-选择素 钙黏蛋白13 压电式机械敏感离子通道组件1 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病]