地屈孕酮与戊酸雌二醇联合治疗女性更年期综合征的疗效及安全性分析  

Analysis of the Efficacy and Safety of the Combination of Dydrogesterone and Estradiol Valerate in the Treatment of Female Menopausal Syndrome

作　　者：井维艳 王静 张晓宇 JING Weiyan;WANG Jing;ZHANG Xiaoyu(Department of Obstetrics and Gynecology,Jiyang District People's Hospital,Jinan,Shandong,251400,China)

机构地区：[1]济阳区人民医院妇产科,山东济南251400

出　　处：《中外医疗》2024年第25期86-90,共5页China & Foreign Medical Treatment

摘　　要：目的探讨地屈孕酮、戊酸雌二醇联合应用于女性更年期综合征的疗效。方法随机选取2022年10月—2023年10月济阳区人民医院收治的60例更年期综合征患者为研究对象,依据不同治疗方法分为对照组和观察组,每组30例。对照组采用戊酸雌二醇、黄体酮联合治疗,观察组采用戊酸雌二醇、地屈孕酮联合治疗。对比两组临床疗效、性激素水平、炎症因子、免疫功能、临床症状、不良反应。结果观察组治疗总有效率为96.67%(29/30),高于对照组的70.00%(21/30),差异有统计学意义(χ^(2)=7.680,P<0.05)。治疗后,观察组孕酮、雌二醇高于对照组,黄体生成素、卵泡生成激素、肿瘤坏死因子α、超敏C反应蛋白、白细胞介素-6、更年期综合征症状评分量表得分均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组T淋巴细胞亚群水平优于对照组,差异有统计学意义(P<0.05)。两组不良反应发生情况对比,差异无统计学意义(P>0.05)。结论地屈孕酮与戊酸雌二醇联合治疗女性更年期综合征有利于临床疗效的提升,对患者性激素水平、炎症因子、免疫功能及临床症状的改善效果良好,且具有较佳的安全性。Objective To explore the therapeutic effects of dexmedroxyprogesterone and estradiol valerate on female menopausal syndrome.Methods From October 2022 to October 2023,60 patients with menopausal syndrome admit⁃ted to Jiyang District People's Hospital were randomly selected as the research objects,according to different treat⁃ment methods,the patients were divided into control group and observation group,with 30 cases in each group.The control group was treated with estradiol valerate and progesterone,while the observation group was treated with estra⁃diol valerate and dydrogesterone.The clinical efficacy,sex hormone levels,inflammatory factors,immune function,clinical symptoms and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%(29/30),which was higher than 70.00%(21/30)in the control group,and the difference was statistically significant(χ^(2)=7.680,P<0.05).After treatment,the levels of progesterone and es⁃tradiol in the observation group were higher than those in the control group,and the levels of luteinizing hormone,follicle-forming hormone,tumor necrosis factor-α,high-sensitivity C-reactive protein,interleukin-6 and Kupperman Menopausal Index score in the observation group were lower than those in the control group,the differences were sta⁃tistically significant(all P<0.05).After treatment,the level of T lymphocyte subsets in the observation group was bet⁃ter than that in the control group,and the difference was statistically significant(P<0.05).There was no significant dif⁃ference in the incidence of adverse reaction between the two groups(P>0.05).Conclusion The combination of dydro⁃gesterone and estradiol valerate in the treatment of female menopausal syndrome is conducive to the improvement of clinical efficacy.It has a good effect on the improvement of sex hormone levels,inflammatory factors,immune function and clinical symptoms,and has better safety.

关 键 词：更年期综合征 地屈孕酮 戊酸雌二醇 临床疗效 安全性 

分 类 号：R711[医药卫生—妇产科学]