干扰素α-2b治疗小儿呼吸道合胞病毒毛细支气管炎的疗效及对患儿血清SP-D、TGF-β及IL-4水平的影响  

Efficacy of Interferonα-2b for Treating Children with Respiratory Syncy⁃tial Virus Bronchiolitis and its Influence on Serum SP-D,TGF-βand IL 4 Levels

作　　者：秦庆员 刘晓玲[2] QIN Qingyuan;LIU Xiaoling(Department of Pediatrics,Shan County Maternal and Child Health Hospital,Heze,Shandong,274300,China;De-partment of Pediatrics,Central Hospital of Shan County,Heze,Shandong,274300,China)

机构地区：[1]单县妇幼保健院儿科,山东菏泽274300 [2]单县中心医院儿科,山东菏泽274300

出　　处：《中外医疗》2024年第25期91-94,共4页China & Foreign Medical Treatment

摘　　要：目的探讨干扰素α-2b在小儿呼吸道合胞病毒(respiratory syncytial virus,RSV)毛细支气管炎患儿中的治疗效果。方法方便选取2021年6月—2023年6月单县妇幼保健院收治的86例RSV毛细支气管炎患儿为研究对象,使用不同治疗方法将其分两组,各43例。对照组采用常规治疗,观察组在对照组基础上添加干扰素α-2b治疗。比较两组临床效果、血清学指标、症状消失时间、治疗安全性。结果观察组治疗总有效率为95.35%(41/43),高于对照组的79.07%(34/43),差异有统计学意义(χ^(2)=5.108,P=0.024)。观察组肺表面活性蛋白D、白介素-4、超敏C反应蛋白、白介素-8及降钙素原均低于对照组,转化生长因子β高于对照组,差异有统计学意义(P均<0.05)。观察组症状消失时间短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论干扰素α-2b可以改善RSV毛细支气管炎患儿临床症状,促进血清学指标复常,不良反应少。Objective To explore the therapeutic effect of interferonα-2b in children with respiratory syncytial virus(RSV)bronchiolitis.Methods A total of 86 children with RSV bronchiolitis admitted to Shan County Maternal and Child Health Hospital from June 2021 to June 2023 were conveniently selected as the research objects.They were di⁃vided into two groups by different treatment methods,with 43 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with interferonα-2b on the basis of the control group.The clinical effect,serological indexes,symptom disappearance time and treatment safety were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.35%(41/43),which was higher than 79.07%(34/43)in the control group,and the difference was statistically significant(χ^(2)=5.108,P=0.024).Pulmonary surfactant protein D,interleukin-4,sensitive C-reactive protein,interleukin-8 and procalcitonin in the ob⁃servation group were lower than those in the control group,and transforming growth factorβwas higher than that in the control group,and the differences were statistically significant(all P<0.05).The disappearance time of symptom in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Con⁃clusion Interferonα-2b can improve clinical symptoms in children with RSV bronchiolitis,promote the normalization of serum indicators,and reduce adverse reactions.

关 键 词：毛细支气管炎 呼吸道合胞病毒 临床疗效 血清学指标 不良反应 

分 类 号：R72[医药卫生—儿科]