探究生长抑素与奥曲肽联合治疗肝硬化伴上消化道出血对患者凝血功能及肝功能指标的影响  

Effect of Somatostatin Combined with Octreotide on Coagulation Function and Liver Function Indexes in Patients with Liver Cirrhosis Complicated with Upper Gastrointestinal Bleeding

作　　者：辛胜 谭占超 郭欣欣 XIN Sheng;TAN Zhanchao;GUO Xinxin(Department of Gastroenterology,Liaocheng People's Hospital,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市人民医院消化内科,山东聊城252000

出　　处：《中外医疗》2024年第25期103-106,共4页China & Foreign Medical Treatment

摘　　要：目的探究对肝硬化(liver cirrhosis,LC)伴上消化道出血(upper gastrointestinal bleeding,UGIB)应用生长抑素与奥曲肽联合治疗的影响。方法方便选择2021年2月—2023年4月聊城市人民医院收治的86例LC伴UGIB患者为研究对象,根据不同治疗方法分为对照组(43例,奥曲肽治疗)和观察组(43例,生长抑素联合奥曲肽治疗)。比较两组凝血功能、肝功能、血氨水平、不良反应。结果治疗后,观察组的凝血酶原时间为(10.08±1.49)s、活化部分凝血活酶时间为(28.13±3.05)s,短于对照组的(12.15±2.11)s和(31.11±3.61)s,纤维蛋白原水平为(2.49±0.43)g/L,高于对照组的(2.16±0.21)g/L,差异有统计学意义(t=5.255、4.135、4.522,P均<0.05)。治疗后,观察组的白蛋白、总胆红素和血氨水平优于对照组,差异有统计学意义(P均<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论在LC伴UGIB患者中,用生长抑素联合奥曲肽治疗能更好地改善患者凝血功能、肝功能,调节血氨水平,且不良反应较少。Objective To explore the effect of somatostatin combined with octreotide on liver cirrhosis(LC)with upper gastrointestinal bleeding(UGIB).Methods A total of 86 patients with LC and UGIB admitted to Liaocheng People's Hospital from February 2021 to April 2023 were conveniently selected as the research objects.According to different treatment methods,they were divided into control group(43 cases,octreotide treatment)and observation group(43 cases,somatostatin combined with octreotide treatment).The coagulation function,liver function,blood ammonia level and adverse reactions were compared between the two groups.Results After treatment,the prothrombin time was(10.08±1.49)s and activated partial thromboplastin time was(28.13±3.05)s in the observation group,which were shorter than(12.15±2.11)s and(31.11±3.61)s in the control group,and the fibrinogen level(2.49±0.43)g/L was higher than that in the control group(2.16±0.21)g/L,the differences were statistically significant(t=5.255,4.135,4.522,all P<0.05).After treatment,the levels of albumin,total bilirubin and blood ammonia in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In patients with LC and UGIB,somatostatin combined with octreotide can better improve coagulation function,liver function,regulate blood ammonia level,and have fewer adverse reactions.

关 键 词：肝硬化 上消化道出血 生长抑素 奥曲肽 凝血功能 肝功能 不良反应 

分 类 号：R4[医药卫生—临床医学]