基于数据挖掘探讨中医药治疗妊娠糖尿病用药规律  

Discussion of Medication Rules of Chinese Medicine for Gestational Diabetes Mellitus Based on Data Mining

作　　者：张辰钧 林燕[1] 杨雪梅[1] 于红虹[1] 黄思敏 葛莉[1] ZHANG Chenjun;LIN Yan;YANG Xuemei;YU Honghong;HUANG Simin;GE Li(Fujian University of Traditional Chinese Medicine,Fuzhou Fujian 350122,China)

机构地区：[1]福建中医药大学,福建福州350122

出　　处：《新中医》2024年第21期10-16,共7页New Chinese Medicine

基　　金：福建中医药大学2020年校管课题(X2020008)。

摘　　要：目的:基于数据挖掘探讨中医药治疗妊娠糖尿病(GDM)用药规律。方法:检索中国知网、万方、维普数据库、PubMed、Web of Science、Embase数据库自建库至2023年2月期间中医治疗GDM的中英文文献并收集处方,对证素及所用中药进行频数分析,对GDM相关证素病机规律、药物配伍规律进行关联规则分析,对GDM高频药物进行聚类分析。结果:共纳入304篇GDM中医临床研究文献,含411条证素诊断记录,347条处方用药记录。GDM病性证素以阴虚、气虚最为常见,病位证素常见于肾、脾、肝。关联规则分析获得证素间的16条主要规则。GDM处方用药涉及128味中药,使用总频次3083次,用药频次≥30次的高频药物28味,药性以寒、温、平为主,药味以甘、苦、辛为主,归经情况以肾、肺、脾、肝、心、胃为多见。关联规则分析获得28条有效药物关联规则,支持度排名前三为:泽泻→山药、女贞子→黄芪、泽泻+茯苓→山药。将28味高频药物聚为4类效果较好。结论:GDM病机中病性以阴虚、气虚最为常见,二者常相伴出现,病位常见于肾、脾、肝,其中肝肾、脾肾间存在关联。GDM用药以甘味,寒、温、平性药为主,药类以滋阴补虚药为主,常用药物之间的配伍以补气生津、健脾补肾为主。Objective:To discuss the medication rules of Chinese medicine for gestational diabetes mellitus(GDM)based on data mining.Methods:The Chinese and English literatures on the treatment of GDM by Chinese medicine were retrieved from China National Knowledge Infrastructure Database,Wanfang data,China Science and Technology Journal Database,PubMed,Web of Science and Embase database from the establishment of the databases to February 2023,and the prescriptions were collected.The frequency analysis of syndrome elements and Chinese medicinals used was carried out;the association rule was used to analyze the etiology of GDM related syndrome elements and compatibility rules of Chinese medicinals;the high-frequency medicines used for GDM was given the cluster analysis.Results:A total of 304 articles concerning the clinical study on Chinese medicine for GDM were included,with 411 diagnostic records of syndrome elements and 347 medication records of prescriptions.The most common syndrome elements of GDM were yin deficiency and qi deficiency,and the syndrome elements of disease location were the kidney,spleen and liver.The association rule analysis suggested 16 main rules between the syndrome elements.GDM medication involved 128 Chinese medicinals,and the total frequency of medicinals use was 3083 times,and 28 high-frequency Chinese medicinals with a frequency of more than or equal to 30 times.The Chinese medicinals were mainly cold,warm and balanced in nature,and their flavors were mainly sweet,bitter and acrid.In terms of the channel entries,the majority was the kidney,lung,spleen,liver,heart and stomach.According to the association rule analysis,28 effective association rules of Chinese medicinals were obtained,and the top three in terms of support were:Alismatis Rhizoma→Dioscoreae Rhizoma and Ligustri Lucidi Fructus→Astragali Radix,Alismatis Rhizoma+Poria→Dioscoreae Rhizoma.It was better to classify 28 highfrequency Chinese medicinals into 4 categories.Conclusion:In the pathogenesis of GDM,yin deficiency and qi defici

关 键 词：妊娠糖尿病 证素 用药规律 数据挖掘 关联规则 聚类分析 

分 类 号：R248.3[医药卫生—中医临床基础]