血府逐瘀汤联合常规西药对下肢动脉硬化闭塞症介入术后患者再狭窄率的影响  

Effect of Xuefu Zhuyu Decoction Combined with Conventional Western Medicine on Restenosis Rate in Patients with Lower-Extremity Arteriosclerosis Obliterans After Interventional Surgery

作　　者：徐巧乐 何倩如 XU Qiaole;HE Qianru(Department of Vascular Surgery,Lishui Central Hospital,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市中心医院血管外科,浙江丽水323000

出　　处：《新中医》2024年第21期38-42,共5页New Chinese Medicine

基　　金：浙江省医药卫生科技计划项目(2021RC146)。

摘　　要：目的:观察血府逐瘀汤联合常规西药对下肢动脉硬化闭塞症(ASO)患者介入治疗后再狭窄率的影响。方法:选取ASO患者86例作为研究对象,按随机数字表法分为研究组和对照组各43例。2组均给予介入治疗,对照组术后给予常规西药治疗,研究组在对照组的基础上加用血府逐瘀汤治疗。评价2组临床疗效,比较2组治疗前后踝肱指数(ABI)、卢瑟福分级(Rutherford)及凝血功能指标[纤维蛋白原(FIB)和凝血酶原时间(PT)]。结果:治疗后,研究组总有效率为93.02%,高于对照组76.74%(P<0.05)。治疗后,2组ABI值较治疗前升高(P<0.05);且研究组ABI值高于对照组(P<0.05)。治疗后,研究组的再狭窄率为13.95%,低于对照组32.56%(P<0.05)。治疗后,2组Rutherford分级在3级以上的例数减少(P<0.05),且研究组少于对照组(P<0.05)。治疗后,2组FIB水平较治疗前降低(P<0.05)。结论:血府逐瘀汤联合常规西药可降低ASO患者介入治疗后再狭窄率,改善踝部动脉血流,促进患者快速康复。Objective:To observe the effect of Xuefu Zhuyu Decoction combined with conventional western medicine on restenosis rate in patients with lower-extremity arteriosclerosis obliterans(ASO)after interventional surgery.Methods:A total of 86 ASO patients were selected as the study subjects and divided into the study group and the control group according to the random number table method,with 43 cases in each group.Both groups were given interventional treatment;the control group was given conventional western medicine after surgery,and the study group was additionally treated with Xuefu Zhuyu Decoction based on the treatment of the control group.The clinical effects were evaluated in the two groups.The Ankle Brachial Index(ABI),Rutherford grading,and coagulation function indicators[fibrinogen(FIB)and prothrombin time(PT)]were compared between the two groups before and after treatment.Results:After treatment,the total effective rate was 93.02%in the study group,higher than that of 76.74%in the control group(P<0.05).After treatment,the ABI in both groups were increased when compared to those before treatment(P<0.05);the ABI in the study group was higher than that in the control group(P<0.05).After treatment,the restenosis rate in the study group was 13.95%,which was lower than that of 32.56%in the control group(P<0.05).After treatment,the number of cases with Rutherford grading above grade 3 in both groups were significantly decreased(P<0.05),and the cases in the study group was less than that in the control group(P<0.05).After treatment,the FIB levels in the two groups were decreased when compared with those before treatment(P<0.05).Conclusion:The combination of Xuefu Zhuyu Decoction and conventional western medicine can reduce the restenosis rate of ASO patients after interventional treatment,improve ankle artery blood flow,and promote the recovery of patients.

关 键 词：下肢动脉硬化闭塞症 前列地尔 血府逐瘀汤 介入治疗 再狭窄 凝血功能 踝肱指数 

分 类 号：R543.5[医药卫生—心血管疾病]