2型糖尿病肾病中医辨证分型与实验室指标及颈动脉内膜中层厚度的相关性研究  

Correlation Between Chinese Medicine Syndrome Differentiation and Laboratory Indexes and Carotid Intima-Media Thickness in Type 2 Diabetic Nephropathy

作　　者：沈鲁佳 李华 严成杰 杨许伟 SHEN Lujia;LI Hua;YAN Chengjie;YANG Xuwei(Department of Pharmacy,The Ninth People's Hospital of Hangzhou,Hangzhou Zhejiang 311225,China)

机构地区：[1]杭州市第九人民医院药剂科,浙江杭州311225

出　　处：《新中医》2024年第21期60-64,共5页New Chinese Medicine

摘　　要：目的:研究2型糖尿病肾病中医辨证分型与实验室指标及颈动脉内膜中层厚度(CIMT)的相关性。方法:选取2型糖尿病肾病患者200例,辨证分型为阴阳两虚证79例、脾肾气虚证51例、气阴两虚证43例、阴虚燥热证27例。比较不同中医辨证分型2型糖尿病肾病患者血清尿素氮(BUN)、肌酐(Cr)、糖化血红蛋白(HbA1c)、肾胺酶(RNLS)、尿β2-微球蛋白(β2-MG)及CIMT水平。采用Pearson相关性分析2型糖尿病肾病中医证型与RNLS、β2-MG、CIMT、BUN、Cr的相关性。结果:4种证型患者血清RNLS、β2-MG、BUN、Cr水平及CIMT比较,差异有统计学意义(P<0.05)。阴阳两虚证患者血清RNLS、β2-MG、BUN、Cr及CIMT水平均高于脾肾气虚证、气阴两虚证、阴虚燥热证(P<0.05)。Pearson相关性分析结果显示,2型糖尿病肾病中医证型与RNLS、β2-MG、CIMT、BUN、Cr均呈正相关(P<0.05)。结论:2型糖尿病肾病患者中气阴两虚证占比最高,其次为脾肾气虚证。不同中医证型患者血清RNLS、β2-MG水平及CIMT存在差异。Objective:To study the correlation between Chinese medicine syndrome differentiation and laboratory indexes and carotid intima-media thickness(CIMT)in type 2 diabetic nephropathy.Methods:A total of 200 cases of patients with type 2 diabetic nephropathy were selected;syndrome differentiation showed that there were 79 cases with yin-yang deficiency syndrome,51 cases with spleen-kidney qi deficiency syndrome,43 cases with qi-yin deficiency syndrome,and 27 cases with yin deficiency and dryness-heat syndrome.The levels of serum urea nitrogen(BUN),creatinine(Cr),glycosylated hemoglobin(HbA1c),renalase(RNLS),urineβ2-microglobulin(β2-MG),and CIMT in patients with type 2 diabetic nephropathy were compared among different Chinese medicine syndrome types.Pearson correlation analysis was used to analyze the correlation between Chinese medicine syndrome types of type 2 diabetic nephropathy and RNLS,β2-MG,CIMT,BUN,and Cr.Results:The comparisons of the levels of serum RNLS,β2-MG,BUN,Cr,and CIMT among patients with four different syndrome types showed significance in the difference(P<0.05).The serum levels of RNLS,β2-MG,BUN,Cr,and CIMT of patients with yin-yang deficiency syndrome were higher than those of patients with spleen-kidney qi deficiency syndrome,qi-yin deficiency syndrome,and yin deficiency and dryness-heat syndrome(P<0.05).Pearson correlation analysis showed that Chinese Medicine syndrome types of type 2 diabetic nephropathy were positively correlated with RNLS,β2-MG,CIMT,BUN,and Cr(P<0.05).Conclusion:Qi-yin deficiency syndrome accounts for the highest proportion of patients with type 2 diabetic nephropathy,followed by spleen-kidney qi deficiency syndrome.There are differences in serum RNLS andβ2-MG levels and CIMT in patients with different Chinese medicine syndrome types.

关 键 词：2型糖尿病肾病 中医证型 肾胺酶 尿Β2-微球蛋白 颈动脉内膜中层厚度 

分 类 号：R587[医药卫生—内分泌] R259[医药卫生—内科学]