替格瑞洛片在急性ST段抬高型心肌梗死患者PCI治疗中的临床疗效及心功能改善研究  

Study on the Clinical Efficacy and Cardiac Function Improvement of Ticagrelor Tablets in Patients with Acute ST-elevation Myocardial Infarction During PCI

作　　者：李俊梅 LI Junmei(Department of Internal Medicine,Heze Mudan People's Hospital of Shandong Province,Heze 274000,Shandong,China)

机构地区：[1]山东省菏泽市牡丹人民医院内科,山东菏泽274000

出　　处：《系统医学》2024年第18期104-107,共4页Systems Medicine

摘　　要：目的分析对于急性ST段抬高型心梗死(ST-elevation myocardial infarction,ASTEMI)并行经皮冠状动脉介入术(percutaneous coronary intervention,PCI)治疗的患者,在治疗过程中合用替格瑞洛片的效果及其对心功能的影响。方法非随机选取山东省菏泽市牡丹人民医院于2021年1月—2023年7月收治的ASTEMI患者92例纳入研究,按照用药方式不同分为对照组和观察组,各46例。对照组采用阿司匹林片+硫酸氢氯吡格雷片治疗,观察组采用阿司匹林片+替格瑞洛片治疗。对比两组患者的疗效、心功能指标、不良事件发生情况。结果观察组的治疗总有效率为95.65%(44/46),高于对照组的82.61%(38/46),差异有统计学意义(χ^(2)=4.039,P<0.05)。观察组的左心室射血分数、峰值射血率指标均高于对照组,左心室舒张末期内径、左心室收缩末期容积指数均低于对照组,差异有统计学意义(P均<0.05)。观察组的不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论在PCI手术过程中使用替格瑞洛片治疗急性ST段抬高型心肌梗死患者具备较好的效果,其能够有效改善患者的心功能,且安全性更高,具有一定的临床意义。Objective To analyze the effect of ticagrelor tablets combined with percutaneous coronary intervention(PCI)on patients with acute ST-elevation myocardial infarction(ASTEMI)and its effect on cardiac function.Methods A total of ninety-two patients with ASTEMI admitted to Heze Mudan People's Hospital of Shandong Province from January 2021 to July 2023 were non-randomly selected and divided into control group and observation group according to different medication methods,with forty-six cases in each group.The control group was treated with aspirin tablets+clopidogrel hydrogen sulfate tablets,and the observation group was treated with aspirin tablets+ticagrelor tablets.The efficacy,cardiac function indexes and adverse events were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.65%(44/46),which was higher than 82.61%(38/46)in the control group,and the difference was statistically significant(χ^(2)=4.039,P<0.05).The left ventricular ejection fraction and peak ejection rate of the observation group were higher than those of the control group,and the left ventricular end-diastolic diameter and left ventricular end-systolic volume index were lower than those of the control group,the differences were statistically significant(all P<0.05).The incidence of adverse events in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The use of ticagrelor tablets in the treatment of patients with acute ST-segment elevation myocardial infarction during PCI surgery has a good effect,which can effectively improve the cardiac function of patients,and has higher safety and certain clinical significance.

关 键 词：急性ST段抬高型心梗死 经皮冠状动脉介入术 替格瑞洛片 治疗效果 

分 类 号：R4[医药卫生—临床医学]