基于生物信息学探讨银屑病合并肥胖的潜在机制及中药预测  

Bioinformatics-based exploration of potential mechanisms and prediction of herbal medicines for psoriasis-associated obesity

作　　者：徐玲云 张峻岭 XU Lingyun;ZHANG Junling(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine,Tianjin 300120,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]天津市中医药研究院附属医院,天津300120

出　　处：《皮肤性病诊疗学杂志》2024年第10期679-686,共8页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广东省重点领域科研项目(2020B1111100005)。

摘　　要：目的通过生物信息学方法探索银屑病合并肥胖状态的核心靶点、重要通路以及潜在治疗中药。方法利用OMIM、GeneCards、DisGeNET、TTD数据库查找银屑病与肥胖两病的共同作用靶点,通过Cytoscape鉴定核心共同靶点。对核心靶点进行GO及KEGG分析以阐明相关生物学过程。最终通过Coremine Medical数据库预测对核心靶点具有调控作用的相关中药。结果银屑病合并肥胖的交集核心靶点基因共13个(IL-6、STAT3、TNF、IL-1B、IL-10、IFNG、CCL2、ICAM1、TLR4、TP53、CRP、PPARG、TYK2)。富集显示上述靶点主要生物学过程涉及STAT受体信号通路和IL-8合成及调节等方面。KEGG分析显示主要涉及炎症性肠病及脂质和动脉粥样硬化通路。中药预测结果显示姜黄、人参、丹参、厚朴花、灵芝、黄连等多味中药具有潜在疗效。这些中药主要归脾胃经、肺经等,多行活血化瘀、补气、祛湿等功效。结论银屑病与肥胖发病共有13个共同核心靶点,其发病与机体持续性炎症及血管改变相关。预测的中药为银屑病合并肥胖的治疗提供了依据。Objective Using bioinformatics methods to explore the core targets and important pathways in and potential therapeutic herbs for psoriasis-associated obesity.Methods OMIM,GeneCards,DisGeNET,and TTD databases were used to identify the common targets of the two diseases,and the core common targets were identified by Cytoscape.The core targets were analyzed by GO and KEGG to elucidate the related biological processes.Finally,the Coremine Medical database was used to predict the related Chinese medicines that regulate the core targets.Results A total of 13 core targets(IL-6,STAT3,TNF,IL-1B,IL-10,IFNG,CCL2,ICAM1,TLR4,TP53,CRP,PPARG,TYK2)were identified as intersecting core targets in obesity associated with psoriasis.Enrichment analysis showed that the main biological processes of these targets were involved the STAT receptor signaling pathway and IL-8 synthesis and regulation,etc.KEGG analysis showed that these genes were mainly involved in inflammatory bowel disease and pathways linked to lipid and atherosclerosis.The prediction results showed that multiple traditional Chinese medicines such as turmeric,ginseng,salvia miltiorrhiza,magnolia,lingzhi,and coptis had potential therapeutic effects.The main effects of these drugs were regulation of the spleen,stomach,lung and other meridians,resulting in activation of blood circulation and removal of blood stasis,tonifying qi,and dispelling dampness.Conclusions Psoriasis and obesity share 13 common core target genes,which are associated with persistent inflammation and vascular changes.The predicted traditional Chinese medicine provides a basis for its utility in the treatment of psoriasis with obesity.

关 键 词：银屑病 肥胖 生物信息学 中药 

分 类 号：R275.9[医药卫生—中西医结合] R259[医药卫生—中医皮科]